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Gene Card

Best human hits

ACVR1B; ACVR1C; TGFBR1

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00012156

Gene Model ID

KH2012:KH.L22.40

Location

KhL22:96803..103061

Transcript Models and Sequences

  KH2012:KH.L22.40.v1.A.ND1-1

External Database Gene Card

External database links

1 result

Database Gene ID
ENSEMBL ENSCING00000014075
Collections

Gateway full ORF

2 results

cima8102456

Plate: VES73_C09

cien220421

Plate: VES104_L11

Gene collection 1 (N. Satoh)

2 results

cieg008p16

Plate: R1CiGC16n06

cicl105b08

Plate: R1CiGC39h20

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term Analysis Definition
TGFB_receptor PANTHER Ser/Thr protein kinase, TGFB receptor
Prot_kinase_dom Pfam Protein kinase domain
Ser/Thr_kinase_AS ProSitePatterns Serine/threonine-protein kinase, active site
Protein_kinase_ATP_BS ProSitePatterns Protein kinase, ATP binding site
GS_dom SMART GS domain
GS_dom Pfam GS domain
Activin_recp Pfam Activin types I and II receptor domain
GS_dom ProSiteProfiles GS domain
Prot_kinase_dom SMART Protein kinase domain
Prot_kinase_dom ProSiteProfiles Protein kinase domain
Kinase-like_dom_sf SUPERFAMILY Protein kinase-like domain superfamily

GOSlim

78 results

GO Term Annotation Origin Type
G1/S transition of mitotic cell cycle Orthology biological process
nucleotide binding Orthology molecular function
angiogenesis Orthology biological process
protein kinase activity Orthology molecular function
protein serine/threonine kinase activity Orthology molecular function
receptor binding Orthology molecular function
protein binding Orthology molecular function
ATP binding Orthology molecular function
cell Orthology cellular component
endosome Orthology cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
integral component of plasma membrane Orthology cellular component
regulation of transcription, DNA-templated Orthology biological process
protein phosphorylation Orthology biological process
apoptotic process Orthology biological process
signal transduction Orthology biological process
central nervous system development Orthology biological process
heart development Orthology biological process
positive regulation of cell proliferation Orthology biological process
regulation of signal transduction Orthology biological process
cell surface Orthology cellular component
regulation of gene expression Orthology biological process
positive regulation of gene expression Orthology biological process
negative regulation of gene expression Orthology biological process
membrane Orthology cellular component
integral component of membrane Orthology cellular component
kinase activity Orthology molecular function
phosphorylation Orthology biological process
transferase activity Orthology molecular function
cell junction Orthology cellular component
cell differentiation Orthology biological process
ubiquitin protein ligase binding Orthology molecular function
intracellular signal transduction Orthology biological process
wound healing Orthology biological process
positive regulation of apoptotic process Orthology biological process
negative regulation of apoptotic process Orthology biological process
intracellular membrane-bounded organelle Orthology cellular component
membrane raft Orthology cellular component
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
protein autophosphorylation Orthology biological process
metal ion binding Orthology molecular function
cell motility Orthology biological process
extracellular exosome Orthology cellular component
positive regulation of catalytic activity Orthology biological process
positive regulation of signal transduction Orthology biological process
system development Orthology biological process
animal organ development Orthology biological process
anatomical structure morphogenesis Orthology biological process
cell surface receptor signaling pathway Orthology biological process
transmembrane signaling receptor activity Orthology molecular function
cellular response to organic substance Orthology biological process
cell migration Orthology biological process
gamete generation Orthology biological process
reproductive process Orthology biological process
response to organic substance Orthology biological process
multicellular organism development Orthology biological process
macromolecular complex binding Orthology molecular function
peptidase activity, acting on L-amino acid peptides Orthology molecular function
extracellular matrix organization Orthology biological process
cellular component organization Orthology biological process
negative regulation of signal transduction Orthology biological process
protein ubiquitination Orthology biological process
regulation of cellular metabolic process Orthology biological process
macromolecular complex Orthology cellular component
endopeptidase activity Orthology molecular function
positive regulation of hydrolase activity Orthology biological process
regulation of molecular function Orthology biological process
immune system process Orthology biological process
protein transport Orthology biological process
cell-cell signaling Orthology biological process
neuron differentiation Orthology biological process
blood vessel morphogenesis Orthology biological process
cell projection assembly Orthology biological process
organelle organization Orthology biological process
anatomical structure development Orthology biological process
regulation of cell proliferation Orthology biological process

GO (Orthology)

124 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
G1/S transition of mitotic cell cycle Hs biological process
nucleotide binding Hs molecular function
activation of MAPKK activity Hs biological process
skeletal system development Hs biological process
angiogenesis Hs biological process
kidney development Hs biological process
epithelial to mesenchymal transition Hs biological process
positive regulation of endothelial cell proliferation Hs biological process
response to dietary excess Hs biological process
lens development in camera-type eye Hs biological process
ventricular trabecula myocardium morphogenesis Hs biological process
protein kinase activity Hs molecular function
protein serine/threonine kinase activity Hs molecular function
transmembrane receptor protein serine/threonine kinase activity Hs molecular function
signal transducer, downstream of receptor, with serine/threonine kinase activity Hs molecular function
transforming growth factor beta-activated receptor activity Hs molecular function
transforming growth factor beta receptor activity, type I Hs molecular function
signal transducer activity, downstream of receptor Hs molecular function
receptor binding Hs molecular function
type II transforming growth factor beta receptor binding Hs molecular function
protein binding Hs molecular function
ATP binding Hs molecular function
cell Hs cellular component
endosome Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
integral component of plasma membrane Hs cellular component
bicellular tight junction Hs cellular component
regulation of transcription, DNA-templated Hs biological process
protein phosphorylation Hs biological process
apoptotic process Hs biological process
cell cycle arrest Hs biological process
signal transduction Hs biological process
transmembrane receptor protein serine/threonine kinase signaling pathway Hs biological process
transforming growth factor beta receptor signaling pathway Hs biological process
central nervous system development Hs biological process
heart development Hs biological process
positive regulation of cell proliferation Hs biological process
germ cell migration Hs biological process
male gonad development Hs biological process
response to glucose Hs biological process
post-embryonic development Hs biological process
anterior/posterior pattern specification Hs biological process
regulation of signal transduction Hs biological process
cell surface Hs cellular component
regulation of gene expression Hs biological process
positive regulation of gene expression Hs biological process
negative regulation of gene expression Hs biological process
regulation of epithelial to mesenchymal transition Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
positive regulation of pathway-restricted SMAD protein phosphorylation Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
kinase activity Hs molecular function
phosphorylation Hs biological process
activin receptor activity, type I Hs molecular function
protein deubiquitination Hs biological process
transferase activity Hs molecular function
activin-activated receptor activity Hs molecular function
peptidyl-serine phosphorylation Hs biological process
peptidyl-threonine phosphorylation Hs biological process
growth factor binding Hs molecular function
lipid storage Hs biological process
signal transduction by protein phosphorylation Hs biological process
cell junction Hs cellular component
cell differentiation Hs biological process
collagen fibril organization Hs biological process
positive regulation of cell growth Hs biological process
negative regulation of cell growth Hs biological process
positive regulation of cell migration Hs biological process
negative regulation of transforming growth factor beta receptor signaling pathway Hs biological process
regulation of protein ubiquitination Hs biological process
ubiquitin protein ligase binding Hs molecular function
response to insulin Hs biological process
activin receptor signaling pathway Hs biological process
positive regulation of activin receptor signaling pathway Hs biological process
inhibin binding Hs molecular function
intracellular signal transduction Hs biological process
nodal signaling pathway Hs biological process
nodal binding Hs molecular function
regulation of growth Hs biological process
wound healing Hs biological process
positive regulation of apoptotic process Hs biological process
negative regulation of apoptotic process Hs biological process
intracellular membrane-bounded organelle Hs cellular component
receptor complex Hs cellular component
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Hs biological process
regulation of protein binding Hs biological process
endothelial cell migration Hs biological process
membrane raft Hs cellular component
positive regulation of erythrocyte differentiation Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
SMAD binding Hs molecular function
development of primary female sexual characteristics Hs biological process
negative regulation of insulin secretion Hs biological process
protein autophosphorylation Hs biological process
metal ion binding Hs molecular function
activin receptor complex Hs cellular component
activin binding Hs molecular function
thymus development Hs biological process
neuron fate commitment Hs biological process
embryonic cranial skeleton morphogenesis Hs biological process
skeletal system morphogenesis Hs biological process
artery morphogenesis Hs biological process
cell motility Hs biological process
transforming growth factor beta binding Hs molecular function
positive regulation of filopodium assembly Hs biological process
positive regulation of stress fiber assembly Hs biological process
positive regulation of protein kinase B signaling Hs biological process
parathyroid gland development Hs biological process
palate development Hs biological process
pharyngeal system development Hs biological process
regulation of cardiac muscle cell proliferation Hs biological process
pathway-restricted SMAD protein phosphorylation Hs biological process
angiogenesis involved in coronary vascular morphogenesis Hs biological process
transforming growth factor beta receptor complex Hs cellular component
extracellular exosome Hs cellular component
I-SMAD binding Hs molecular function
cellular response to transforming growth factor beta stimulus Hs biological process
extrinsic apoptotic signaling pathway Hs biological process
positive regulation of trophoblast cell migration Hs biological process
positive regulation of apoptotic signaling pathway Hs biological process
negative regulation of extrinsic apoptotic signaling pathway Hs biological process

GO (Blast)

41 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nucleotide binding Hs molecular function 521 0.0
protein kinase activity Hs molecular function 521 0.0
protein serine/threonine kinase activity Hs molecular function 521 0.0
transmembrane receptor protein serine/threonine kinase activity Hs molecular function 521 0.0
signal transducer, downstream of receptor, with serine/threonine kinase activity Hs molecular function 521 0.0
transforming growth factor beta-activated receptor activity Hs molecular function 521 0.0
transforming growth factor beta receptor activity, type I Hs molecular function 521 0.0
signal transducer activity, downstream of receptor Hs molecular function 521 0.0
receptor binding Hs molecular function 521 0.0
type II transforming growth factor beta receptor binding Hs molecular function 521 0.0
protein binding Hs molecular function 521 0.0
ATP binding Hs molecular function 521 0.0
cell Hs cellular component 521 0.0
endosome Hs cellular component 521 0.0
cytosol Hs cellular component 473 7.82e-164
plasma membrane Hs cellular component 521 0.0
integral component of plasma membrane Hs cellular component 473 7.82e-164
bicellular tight junction Hs cellular component 521 0.0
cell surface Hs cellular component 521 0.0
membrane Hs cellular component 521 0.0
integral component of membrane Hs cellular component 521 0.0
kinase activity Hs molecular function 521 0.0
activin receptor activity, type I Hs molecular function 479 3.53e-167
transferase activity Hs molecular function 521 0.0
activin-activated receptor activity Hs molecular function 473 7.82e-164
growth factor binding Hs molecular function 521 0.0
cell junction Hs cellular component 521 0.0
ubiquitin protein ligase binding Hs molecular function 473 7.82e-164
inhibin binding Hs molecular function 473 7.82e-164
nodal binding Hs molecular function 479 3.53e-167
intracellular membrane-bounded organelle Hs cellular component 521 0.0
receptor complex Hs cellular component 521 0.0
membrane raft Hs cellular component 521 0.0
SMAD binding Hs molecular function 521 0.0
metal ion binding Hs molecular function 521 0.0
activin receptor complex Hs cellular component 479 3.53e-167
activin binding Hs molecular function 473 7.82e-164
transforming growth factor beta binding Hs molecular function 521 0.0
transforming growth factor beta receptor complex Hs cellular component 521 0.0
extracellular exosome Hs cellular component 473 7.82e-164
I-SMAD binding Hs molecular function 521 0.0

GO (InterProScan)

7 results

GO Term Analysis Type e-value
protein kinase activity Pfam molecular function 1.7E-36
transmembrane receptor protein serine/threonine kinase activity Pfam molecular function 1.4E-13
signal transducer, downstream of receptor, with serine/threonine kinase activity PANTHER molecular function 3.2E-191
ATP binding PANTHER molecular function 3.2E-191
protein phosphorylation Pfam biological process 1.7E-36
transmembrane receptor protein serine/threonine kinase signaling pathway PANTHER biological process 3.2E-191
membrane PANTHER cellular component 3.2E-191

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