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GENE CARD

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Gene Card

Best human hits

BMP10; GDF2; NODAL

Unique Gene ID

Cirobu.g00010576

Gene Model ID

KH2012:KH.L106.16

Location

KhL106:35269..37584

Transcript Models and Sequences

  KH2012:KH.L106.16.v1.A.SL1-1

External Database Gene Card

External database links

2 results

Collections

Gateway full ORF

2 results

cien55224

Plate: VES78_E23

cien86601

Plate: VES83_J21

Gene collection 1 (N. Satoh)

1 result

cicl090l02

Plate: R1CiGC39d05

WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Gene Phylogeny

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Gene Annotations

InterPro

7 results

IPR Term Analysis Definition
TGFb_CS ProSitePatterns Transforming growth factor beta, conserved site
Cystine-knot_cytokine Gene3D Cystine-knot cytokine
TGF-b_C Pfam Transforming growth factor-beta, C-terminal
TGF-b_C ProSiteProfiles Transforming growth factor-beta, C-terminal
Cystine-knot_cytokine SUPERFAMILY Cystine-knot cytokine
TGF-b_C SMART Transforming growth factor-beta, C-terminal
TGF-beta-rel PANTHER Transforming growth factor-beta-related

GOSlim

45 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
angiogenesis Orthology biological process
vasculature development Orthology biological process
protein binding Blast molecular function
extracellular region Orthology cellular component
extracellular space Orthology cellular component
cell Blast cellular component
cytoplasm Blast cellular component
cell adhesion Orthology biological process
multicellular organism development Orthology biological process
nervous system development Orthology biological process
brain development Orthology biological process
heart development Orthology biological process
positive regulation of cell proliferation Orthology biological process
regulation of signal transduction Orthology biological process
cell surface Blast cellular component
cell migration Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
cell development Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
extracellular exosome Blast cellular component
animal organ development Orthology biological process
anatomical structure morphogenesis Orthology biological process
receptor binding Orthology molecular function
molecular function regulator Orthology molecular function
signaling receptor activity Orthology molecular function
anatomical structure development Orthology biological process
regulation of molecular function Orthology biological process
cell surface receptor signaling pathway Orthology biological process
positive regulation of signal transduction Orthology biological process
protein phosphorylation Orthology biological process
developmental process Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
cellular response to organic substance Orthology biological process
cell differentiation Orthology biological process
endopeptidase activity Orthology molecular function
positive regulation of hydrolase activity Orthology biological process
positive regulation of apoptotic process Orthology biological process
system development Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
intracellular signal transduction Orthology biological process
organelle part Blast cellular component
cytoplasmic part Blast cellular component
intracellular non-membrane-bounded organelle Blast cellular component
cytoskeletal protein binding Blast molecular function

GO (Orthology)

59 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
gastrulation with mouth forming second Hs biological process
mesoderm formation Hs biological process
liver development Hs biological process
vasculature development Hs biological process
heart looping Hs biological process
cytokine activity Hs molecular function
transforming growth factor beta receptor binding Hs molecular function
extracellular region Hs cellular component
extracellular space Hs cellular component
multicellular organism development Hs biological process
determination of left/right symmetry Hs biological process
gastrulation Hs biological process
nervous system development Hs biological process
brain development Hs biological process
endoderm development Hs biological process
heart development Hs biological process
growth factor activity Hs molecular function
positive regulation of cell proliferation Hs biological process
embryonic pattern specification Hs biological process
anterior/posterior axis specification Hs biological process
anterior/posterior pattern specification Hs biological process
regulation of signal transduction Hs biological process
polarity specification of proximal/distal axis Hs biological process
regulation of receptor activity Hs biological process
regulation of gastrulation Hs biological process
positive regulation of vascular endothelial growth factor production Hs biological process
positive regulation of pathway-restricted SMAD protein phosphorylation Hs biological process
morphogen activity Hs molecular function
cell migration Hs biological process
stem cell population maintenance Hs biological process
positive regulation of cell-cell adhesion Hs biological process
lung development Hs biological process
BMP signaling pathway Hs biological process
positive regulation of activin receptor signaling pathway Hs biological process
embryonic heart tube development Hs biological process
endodermal cell differentiation Hs biological process
nodal signaling pathway Hs biological process
cell migration involved in gastrulation Hs biological process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Hs biological process
cell fate commitment Hs biological process
negative regulation of cell differentiation Hs biological process
positive regulation of angiogenesis Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
receptor ligand activity Hs molecular function
mesendoderm development Hs biological process
cell development Hs biological process
digestive tract morphogenesis Hs biological process
anatomical structure formation involved in morphogenesis Hs biological process
embryonic cranial skeleton morphogenesis Hs biological process
tissue morphogenesis Hs biological process
formation of anatomical boundary Hs biological process
positive regulation of epithelial cell proliferation Hs biological process
positive regulation of sequence-specific DNA binding transcription factor activity Hs biological process
digestive system development Hs biological process
SMAD protein signal transduction Hs biological process
positive regulation of ERK1 and ERK2 cascade Hs biological process
type I activin receptor binding Hs molecular function
primitive streak formation Hs biological process

GO (Blast)

17 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type Score E-value
cytokine activity Hs molecular function 140 3.20e-38
transforming growth factor beta receptor binding Hs molecular function 140 3.20e-38
hormone activity Hs molecular function 117 4.07e-29
protein binding Hs molecular function 117 4.07e-29
extracellular region Hs cellular component 140 3.20e-38
extracellular space Hs cellular component 140 3.20e-38
cell Hs cellular component 115 1.96e-28
cytoplasm Hs cellular component 117 4.07e-29
growth factor activity Hs molecular function 140 3.20e-38
cell surface Hs cellular component 117 4.07e-29
morphogen activity Hs molecular function 140 3.20e-38
Z disc Hs cellular component 117 4.07e-29
telethonin binding Hs molecular function 117 4.07e-29
receptor serine/threonine kinase binding Hs molecular function 117 4.07e-29
receptor ligand activity Hs molecular function 140 3.20e-38
extracellular exosome Hs cellular component 115 1.96e-28
type I activin receptor binding Hs molecular function 140 3.20e-38

GO (InterProScan)

1 result

GO Term Analysis Type e-value
growth factor activity SMART molecular function 3.5E-54