Database	Gene ID
ENSEMBL	ENSCING00000008347
ENSEMBL	ENSCING00000019068
NCBI Reference Sequence	NM_001047991.1

IPR Term	Analysis	Definition
HATPase_C_sf	Gene3D	Histidine kinase/HSP90-like ATPase superfamily
Topo_IIA_A/C	SMART	DNA topoisomerase, type IIA, subunit A/C-terminal
HATPase_C	CDD	Histidine kinase/HSP90-like ATPase
Topo_IIA-like_dom_sf	SUPERFAMILY	DNA topoisomerase, type IIA-like domain superfamily
TOPRIM_domain	ProSiteProfiles	TOPRIM domain
TopoIIA_CS	ProSitePatterns	DNA topoisomerase, type IIA, conserved site
TopoII_euk	PRINTS	DNA topoisomerase II, eukaryotic-type
HATPase_C	SMART	Histidine kinase/HSP90-like ATPase
Topo_IIA	SMART	DNA topoisomerase, type IIA
HATPase_C_sf	SUPERFAMILY	Histidine kinase/HSP90-like ATPase superfamily
TOPRIM_C	Pfam	C-terminal associated domain of TOPRIM
Topo_IIA_A/C	Pfam	DNA topoisomerase, type IIA, subunit A/C-terminal
Topo_IIA	PANTHER	DNA topoisomerase, type IIA
TOPRIM_domain	Pfam	TOPRIM domain
Topo_IIA_bsu_dom2	Pfam	DNA topoisomerase, type IIA, subunit B, domain 2
Ribosomal_S5_D2-typ_fold_subgr	Gene3D	Ribosomal protein S5 domain 2-type fold, subgroup
HATPase_C	Pfam	Histidine kinase/HSP90-like ATPase
Topo_IIA_A/C_ab	Gene3D	DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
Topo_IIA_B_C	Gene3D	DNA topoisomerase, type IIA, subunit B, C-terminal
Ribosomal_S5_D2-typ_fold	SUPERFAMILY	Ribosomal protein S5 domain 2-type fold
Topo_IIA_A_a_sf	Gene3D	Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
TOPRIM_TopoII	CDD	DNA topoisomerase 2, TOPRIM domain

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
magnesium ion binding	Orthology	molecular function
DNA binding	Orthology	molecular function
chromatin binding	Orthology	molecular function
RNA binding	Orthology	molecular function
protein binding	Orthology	molecular function
ATP binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
nucleolus	Orthology	cellular component
cytoplasm	Orthology	cellular component
cytosol	Orthology	cellular component
DNA metabolic process	Orthology	biological process
cellular response to DNA damage stimulus	Orthology	biological process
axonogenesis	Orthology	biological process
protein C-terminus binding	Orthology	molecular function
enzyme binding	Orthology	molecular function
macromolecular complex	Orthology	cellular component
protein homodimerization activity	Orthology	molecular function
positive regulation of apoptotic process	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
metal ion binding	Orthology	molecular function
protein heterodimerization activity	Orthology	molecular function
intracellular non-membrane-bounded organelle	Orthology	cellular component
nuclear lumen	Orthology	cellular component
reproductive process	Orthology	biological process
intracellular organelle part	Orthology	cellular component
organelle organization	Orthology	biological process
cell migration	Orthology	biological process
generation of neurons	Orthology	biological process
animal organ development	Orthology	biological process
immune system process	Orthology	biological process
cell differentiation	Orthology	biological process
catalytic activity	Orthology	molecular function
nucleoside-triphosphatase activity	Orthology	molecular function
protein kinase binding	Orthology	molecular function
cytoplasmic part	Orthology	cellular component
microtubule organizing center	Orthology	cellular component
cellular process	Orthology	biological process
binding	Orthology	molecular function
intracellular part	Orthology	cellular component
protein modification by small protein conjugation	Orthology	biological process
brain development	Orthology	biological process
cell division	Orthology	biological process
multicellular organism development	Orthology	biological process
macromolecular complex binding	Orthology	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
nucleotide binding	Hs	molecular function
nuclear chromosome	Hs	cellular component
magnesium ion binding	Hs	molecular function
resolution of meiotic recombination intermediates	Hs	biological process
heterochromatin	Hs	cellular component
condensed chromosome	Hs	cellular component
sister chromatid segregation	Hs	biological process
neuron migration	Hs	biological process
hematopoietic progenitor cell differentiation	Hs	biological process
DNA binding	Hs	molecular function
chromatin binding	Hs	molecular function
RNA binding	Hs	molecular function
DNA topoisomerase activity	Hs	molecular function
DNA topoisomerase type II (ATP-hydrolyzing) activity	Hs	molecular function
protein kinase C binding	Hs	molecular function
protein binding	Hs	molecular function
ATP binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
nucleolus	Hs	cellular component
cytoplasm	Hs	cellular component
centriole	Hs	cellular component
cytosol	Hs	cellular component
DNA metabolic process	Hs	biological process
DNA topological change	Hs	biological process
DNA ligation	Hs	biological process
cellular response to DNA damage stimulus	Hs	biological process
chromosome segregation	Hs	biological process
axonogenesis	Hs	biological process
protein C-terminus binding	Hs	molecular function
DNA-dependent ATPase activity	Hs	molecular function
drug binding	Hs	molecular function
DNA binding, bending	Hs	molecular function
DNA topoisomerase complex (ATP-hydrolyzing)	Hs	cellular component
isomerase activity	Hs	molecular function
protein sumoylation	Hs	biological process
viral integration complex	Hs	cellular component
enzyme binding	Hs	molecular function
chromosome condensation	Hs	biological process
intracellular ribonucleoprotein complex	Hs	cellular component
forebrain development	Hs	biological process
macromolecular complex	Hs	cellular component
embryonic cleavage	Hs	biological process
regulation of circadian rhythm	Hs	biological process
protein homodimerization activity	Hs	molecular function
histone deacetylase binding	Hs	molecular function
ribonucleoprotein complex binding	Hs	molecular function
positive regulation of apoptotic process	Hs	biological process
ubiquitin binding	Hs	molecular function
mitotic DNA integrity checkpoint	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
metal ion binding	Hs	molecular function
protein heterodimerization activity	Hs	molecular function
rhythmic process	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	1688	0.0
nuclear chromosome	Hs	cellular component	1686	0.0
magnesium ion binding	Hs	molecular function	1686	0.0
heterochromatin	Hs	cellular component	1688	0.0
condensed chromosome	Hs	cellular component	1686	0.0
DNA binding	Hs	molecular function	1688	0.0
chromatin binding	Hs	molecular function	1688	0.0
RNA binding	Hs	molecular function	1686	0.0
DNA topoisomerase activity	Hs	molecular function	1688	0.0
DNA topoisomerase type II (ATP-hydrolyzing) activity	Hs	molecular function	1688	0.0
protein kinase C binding	Hs	molecular function	1688	0.0
protein binding	Hs	molecular function	1686	0.0
ATP binding	Hs	molecular function	1688	0.0
nucleus	Hs	cellular component	1688	0.0
nucleoplasm	Hs	cellular component	1688	0.0
nucleolus	Hs	cellular component	1686	0.0
cytoplasm	Hs	cellular component	1688	0.0
centriole	Hs	cellular component	1686	0.0
cytosol	Hs	cellular component	1688	0.0
protein C-terminus binding	Hs	molecular function	1688	0.0
DNA-dependent ATPase activity	Hs	molecular function	1686	0.0
drug binding	Hs	molecular function	1686	0.0
DNA binding, bending	Hs	molecular function	1686	0.0
DNA topoisomerase complex (ATP-hydrolyzing)	Hs	cellular component	1686	0.0
isomerase activity	Hs	molecular function	1688	0.0
viral integration complex	Hs	cellular component	1686	0.0
enzyme binding	Hs	molecular function	1688	0.0
intracellular ribonucleoprotein complex	Hs	cellular component	1688	0.0
macromolecular complex	Hs	cellular component	1686	0.0
protein homodimerization activity	Hs	molecular function	1686	0.0
histone deacetylase binding	Hs	molecular function	1688	0.0
ribonucleoprotein complex binding	Hs	molecular function	1688	0.0
ubiquitin binding	Hs	molecular function	1686	0.0
metal ion binding	Hs	molecular function	1688	0.0
protein heterodimerization activity	Hs	molecular function	1688	0.0

GO Term	Analysis	Type	e-value
DNA binding	PANTHER	molecular function	0.0
DNA topoisomerase type II (ATP-hydrolyzing) activity	PANTHER	molecular function	0.0
ATP binding	PANTHER	molecular function	0.0
DNA metabolic process	Gene3D	biological process	8.1E-189
DNA topological change	PANTHER	biological process	0.0