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GENE CARD

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Gene Card

Best human hits

MYD88; SIGIRR; TLR3

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00009516

Gene Model ID

KH2012:KH.C8.842

Location

KhC8:1728048..1731980

Transcript Models and Sequences

  KH2012:KH.C8.842.v1.A.ND1-1

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000009957
ENSEMBL ENSCING00000017616
Collections

Gateway full ORF

2 results

cima879404

Plate: VES68_I12

cima882572

Plate: VES69_N04

Gene collection 1 (N. Satoh)

1 result

ciad050m03

Plate: R1CiGC05k16

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

9 results

IPR Term Analysis Definition
Toll_tir_struct_dom_sf SUPERFAMILY Toll/interleukin-1 receptor homology (TIR) domain superfamily
TIR_dom Pfam Toll/interleukin-1 receptor homology (TIR) domain
Toll_tir_struct_dom_sf Gene3D Toll/interleukin-1 receptor homology (TIR) domain superfamily
TIR_dom ProSiteProfiles Toll/interleukin-1 receptor homology (TIR) domain
TIR_dom SMART Toll/interleukin-1 receptor homology (TIR) domain
Death_domain Pfam Death domain
MyD88_Death CDD MyD88, death domain
Death_domain ProSiteProfiles Death domain
DEATH-like_dom_sf SUPERFAMILY Death-like domain superfamily

GOSlim

49 results

GO Term Annotation Origin Type
Golgi membrane Blast cellular component
immune system process Orthology biological process
RNA binding Blast molecular function
transmembrane signaling receptor activity Blast molecular function
receptor binding Orthology molecular function
protein binding Orthology molecular function
intracellular Blast cellular component
nucleus Orthology cellular component
cytoplasm Orthology cellular component
lysosomal membrane Blast cellular component
endosome Orthology cellular component
early endosome Blast cellular component
endoplasmic reticulum Blast cellular component
endoplasmic reticulum membrane Blast cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
integral component of plasma membrane Blast cellular component
apoptotic process Orthology biological process
defense response Orthology biological process
signal transduction Orthology biological process
cell surface receptor signaling pathway Orthology biological process
regulation of gene expression Orthology biological process
positive regulation of gene expression Orthology biological process
membrane Blast cellular component
integral component of membrane Blast cellular component
cytokine-mediated signaling pathway Orthology biological process
response to lipopolysaccharide Orthology biological process
regulation of cell proliferation Orthology biological process
identical protein binding Orthology molecular function
negative regulation of apoptotic process Orthology biological process
innate immune response Orthology biological process
cellular response to stress Orthology biological process
intracellular signal transduction Orthology biological process
protein phosphorylation Orthology biological process
intracellular organelle part Orthology cellular component
whole membrane Orthology cellular component
bounding membrane of organelle Orthology cellular component
organelle Orthology cellular component
postsynapse Orthology cellular component
neuron part Orthology cellular component
immune response Orthology biological process
cellular response to organic substance Orthology biological process
response to molecule of bacterial origin Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
positive regulation of signal transduction Orthology biological process
response to bacterium Orthology biological process
mRNA catabolic process Orthology biological process
cell development Orthology biological process
cell migration Orthology biological process

GO (Orthology)

48 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
toll-like receptor signaling pathway Hs biological process
immune system process Hs biological process
MyD88-dependent toll-like receptor signaling pathway Hs biological process
receptor binding Hs molecular function
Toll binding Hs molecular function
death receptor binding Hs molecular function
interleukin-1 receptor binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
apoptotic process Hs biological process
inflammatory response Hs biological process
signal transduction Hs biological process
cell surface receptor signaling pathway Hs biological process
JNK cascade Hs biological process
Toll signaling pathway Hs biological process
response to virus Hs biological process
endosome membrane Hs cellular component
regulation of gene expression Hs biological process
positive regulation of gene expression Hs biological process
postsynaptic density Hs cellular component
immunoglobulin mediated immune response Hs biological process
cytokine-mediated signaling pathway Hs biological process
lipopolysaccharide-mediated signaling pathway Hs biological process
positive regulation of type I interferon production Hs biological process
response to peptidoglycan Hs biological process
response to lipopolysaccharide Hs biological process
toll-like receptor 9 signaling pathway Hs biological process
Toll-like receptor binding Hs molecular function
regulation of cell proliferation Hs biological process
identical protein binding Hs molecular function
negative regulation of apoptotic process Hs biological process
positive regulation of I-kappaB kinase/NF-kappaB signaling Hs biological process
protein self-association Hs molecular function
negative regulation of growth of symbiont in host Hs biological process
innate immune response Hs biological process
positive regulation of JNK cascade Hs biological process
regulation of inflammatory response Hs biological process
defense response to Gram-positive bacterium Hs biological process
positive regulation of NF-kappaB transcription factor activity Hs biological process
interleukin-1-mediated signaling pathway Hs biological process
3'-UTR-mediated mRNA stabilization Hs biological process
TIR domain binding Hs molecular function
cellular response to mechanical stimulus Hs biological process
establishment of endothelial intestinal barrier Hs biological process
regulation of neutrophil migration Hs biological process

GO (Blast)

30 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
Golgi membrane Hs cellular component 38.5 0.009
RNA binding Hs molecular function 38.5 0.009
double-stranded RNA binding Hs molecular function 38.5 0.009
receptor activity Hs molecular function 38.5 0.009
transmembrane signaling receptor activity Hs molecular function 38.5 0.009
receptor binding Hs molecular function 117 1.30e-29
Toll binding Hs molecular function 117 1.30e-29
death receptor binding Hs molecular function 117 1.30e-29
interleukin-1 receptor binding Hs molecular function 117 1.30e-29
protein binding Hs molecular function 117 1.30e-29
intracellular Hs cellular component 38.5 0.009
nucleus Hs cellular component 117 1.30e-29
cytoplasm Hs cellular component 117 1.30e-29
lysosomal membrane Hs cellular component 38.5 0.009
endosome Hs cellular component 38.5 0.009
early endosome Hs cellular component 38.5 0.009
endoplasmic reticulum Hs cellular component 38.5 0.009
endoplasmic reticulum membrane Hs cellular component 38.5 0.009
cytosol Hs cellular component 117 1.30e-29
plasma membrane Hs cellular component 117 1.30e-29
integral component of plasma membrane Hs cellular component 38.5 0.009
endosome membrane Hs cellular component 117 1.30e-29
postsynaptic density Hs cellular component 117 1.30e-29
membrane Hs cellular component 46.2 2.61e-05
integral component of membrane Hs cellular component 46.2 2.61e-05
Toll-like receptor binding Hs molecular function 117 1.30e-29
endolysosome membrane Hs cellular component 38.5 0.009
identical protein binding Hs molecular function 117 1.30e-29
protein self-association Hs molecular function 117 1.30e-29
TIR domain binding Hs molecular function 117 1.30e-29

GO (InterProScan)

2 results

GO Term Analysis Type e-value
protein binding CDD molecular function 5.65966E-25
signal transduction CDD biological process 5.65966E-25

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