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Gene Card

Best human hits

PAK1; PAK2; PAK3

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00008699

Gene Model ID

KH2012:KH.C7.98

Location

KhC7:2725981..2738209

Transcript Models and Sequences

  KH2012:KH.C7.98.v1.A.SL1-1
KH2012:KH.C7.98.v1.A.SL2-1

External Database Gene Card

External database links

1 result

Database Gene ID
NCBI Reference Sequence XM_002131063.3
Collections

Gateway full ORF

2 results

cien60562

Plate: VES79_M18

cien70325

Plate: VES81_E09

Gene collection 1 (N. Satoh)

2 results

cicl017p20

Plate: R1CiGC10l01

cicl022i02

Plate: R1CiGC11i06

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term Analysis Definition
Protein_kinase_ATP_BS ProSitePatterns Protein kinase, ATP binding site
Ser/Thr_kinase_AS ProSitePatterns Serine/threonine-protein kinase, active site
CRIB_dom ProSiteProfiles CRIB domain
Prot_kinase_dom SMART Protein kinase domain
Kinase-like_dom_sf SUPERFAMILY Protein kinase-like domain superfamily
CRIB_dom_sf Gene3D CRIB domain superfamily
Prot_kinase_dom ProSiteProfiles Protein kinase domain
Prot_kinase_dom Pfam Protein kinase domain
CRIB_dom Pfam CRIB domain
PAK_BD CDD p21 activated kinase binding domain
CRIB_dom SMART CRIB domain

GOSlim

76 results

GO Term Annotation Origin Type
nucleotide binding Orthology molecular function
response to hypoxia Orthology biological process
catalytic activity Orthology molecular function
protein kinase activity Orthology molecular function
protein serine/threonine kinase activity Orthology molecular function
protein binding Orthology molecular function
ATP binding Orthology molecular function
nucleus Orthology cellular component
cytoplasm Orthology cellular component
endosome Orthology cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
focal adhesion Orthology cellular component
protein phosphorylation Orthology biological process
apoptotic process Orthology biological process
signal transduction Orthology biological process
multicellular organism development Orthology biological process
axonogenesis Orthology biological process
metabolic process Orthology biological process
positive regulation of cell proliferation Orthology biological process
response to organic substance Orthology biological process
membrane Orthology cellular component
kinase activity Orthology molecular function
phosphorylation Orthology biological process
cell migration Orthology biological process
transferase activity Orthology molecular function
protein kinase binding Orthology molecular function
lamellipodium Orthology cellular component
cell junction Orthology cellular component
axon Orthology cellular component
nuclear membrane Orthology cellular component
macromolecular complex Orthology cellular component
wound healing Orthology biological process
identical protein binding Orthology molecular function
regulation of apoptotic process Orthology biological process
cell projection Orthology cellular component
negative regulation of apoptotic process Orthology biological process
protein autophosphorylation Orthology biological process
metal ion binding Orthology molecular function
perinuclear region of cytoplasm Orthology cellular component
neuron projection morphogenesis Orthology biological process
intracellular signal transduction Orthology biological process
positive regulation of catalytic activity Orthology biological process
positive regulation of signal transduction Orthology biological process
plasma membrane region Orthology cellular component
cell leading edge Orthology cellular component
macromolecular complex binding Orthology molecular function
regulation of catalytic activity Orthology biological process
membrane organization Orthology biological process
organelle organization Orthology biological process
small GTPase mediated signal transduction Orthology biological process
neuron projection development Orthology biological process
enzyme binding Orthology molecular function
brain development Orthology biological process
cellular process Orthology biological process
organelle part Orthology cellular component
cytoplasmic part Orthology cellular component
intracellular non-membrane-bounded organelle Orthology cellular component
enzyme activator activity Orthology molecular function
cellular response to stress Orthology biological process
microtubule-based process Orthology biological process
cytoskeletal part Orthology cellular component
cell projection membrane Orthology cellular component
cellular response to organic substance Orthology biological process
cell surface receptor signaling pathway Orthology biological process
immune response Orthology biological process
regulation of signal transduction Orthology biological process
regulation of cellular metabolic process Orthology biological process
positive regulation of apoptotic process Orthology biological process
cell adhesion molecule binding Orthology molecular function
anatomical structure morphogenesis Orthology biological process
cellular component organization Orthology biological process
cell morphogenesis involved in neuron differentiation Orthology biological process
protein targeting to membrane Orthology biological process
endopeptidase activity Orthology molecular function
cell projection assembly Orthology biological process

GO (Orthology)

105 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
MAPK cascade Hs biological process
nucleotide binding Hs molecular function
activation of MAPK activity Hs biological process
response to hypoxia Hs biological process
ruffle Hs cellular component
positive regulation of protein phosphorylation Hs biological process
catalytic activity Hs molecular function
protein kinase activity Hs molecular function
protein serine/threonine kinase activity Hs molecular function
MAP kinase kinase activity Hs molecular function
protein binding Hs molecular function
collagen binding Hs molecular function
ATP binding Hs molecular function
nucleus Hs cellular component
cytoplasm Hs cellular component
endosome Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
cell-cell junction Hs cellular component
focal adhesion Hs cellular component
protein phosphorylation Hs biological process
negative regulation of protein kinase activity Hs biological process
exocytosis Hs biological process
apoptotic process Hs biological process
signal transduction Hs biological process
Rho protein signal transduction Hs biological process
multicellular organism development Hs biological process
regulation of mitotic cell cycle Hs biological process
axonogenesis Hs biological process
metabolic process Hs biological process
positive regulation of cell proliferation Hs biological process
response to organic substance Hs biological process
regulation of neuron projection development Hs biological process
intercalated disc Hs cellular component
membrane Hs cellular component
viral process Hs biological process
kinase activity Hs molecular function
phosphorylation Hs biological process
dendrite development Hs biological process
cell migration Hs biological process
transferase activity Hs molecular function
Rho GTPase binding Hs molecular function
SH3 domain binding Hs molecular function
peptidyl-serine phosphorylation Hs biological process
protein kinase binding Hs molecular function
cerebellum development Hs biological process
signal transduction by protein phosphorylation Hs biological process
establishment of cell polarity Hs biological process
Z disc Hs cellular component
lamellipodium Hs cellular component
actin cytoskeleton organization Hs biological process
cell junction Hs cellular component
protein tyrosine kinase activator activity Hs molecular function
positive regulation of cell migration Hs biological process
axon Hs cellular component
dendrite Hs cellular component
regulation of actin filament polymerization Hs biological process
stress-activated protein kinase signaling cascade Hs biological process
positive regulation of microtubule polymerization Hs biological process
small GTPase binding Hs molecular function
actin cytoskeleton reorganization Hs biological process
filamentous actin Hs cellular component
nuclear membrane Hs cellular component
activation of protein kinase activity Hs biological process
ruffle membrane Hs cellular component
cellular response to insulin stimulus Hs biological process
regulation of actin cytoskeleton organization Hs biological process
macromolecular complex Hs cellular component
positive regulation of peptidyl-serine phosphorylation Hs biological process
Fc-epsilon receptor signaling pathway Hs biological process
regulation of growth Hs biological process
wound healing Hs biological process
identical protein binding Hs molecular function
regulation of apoptotic process Hs biological process
cell projection Hs cellular component
negative regulation of apoptotic process Hs biological process
regulation of MAPK cascade Hs biological process
positive regulation of JUN kinase activity Hs biological process
positive regulation of neuron apoptotic process Hs biological process
cadherin binding Hs molecular function
positive regulation of axon extension Hs biological process
protein autophosphorylation Hs biological process
metal ion binding Hs molecular function
vascular endothelial growth factor receptor signaling pathway Hs biological process
hepatocyte growth factor receptor signaling pathway Hs biological process
ephrin receptor signaling pathway Hs biological process
Rac GTPase binding Hs molecular function
perinuclear region of cytoplasm Hs cellular component
branching morphogenesis of an epithelial tube Hs biological process
neuron projection morphogenesis Hs biological process
positive regulation of peptidyl-tyrosine phosphorylation Hs biological process
regulation of axonogenesis Hs biological process
synapse organization Hs biological process
T cell receptor signaling pathway Hs biological process
GTPase binding Hs molecular function
positive regulation of stress fiber assembly Hs biological process
dendritic spine development Hs biological process
dendritic spine morphogenesis Hs biological process
positive regulation of dendritic spine morphogenesis Hs biological process
positive regulation of protein tyrosine kinase activity Hs biological process
cellular response to organic cyclic compound Hs biological process
invadopodium Hs cellular component
positive regulation of protein targeting to membrane Hs biological process
positive regulation of extrinsic apoptotic signaling pathway Hs biological process
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Hs biological process

GO (Blast)

42 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nucleotide binding Hs molecular function 696 0.0
ruffle Hs cellular component 693 0.0
catalytic activity Hs molecular function 696 0.0
protein kinase activity Hs molecular function 696 0.0
protein serine/threonine kinase activity Hs molecular function 696 0.0
MAP kinase kinase activity Hs molecular function 696 0.0
protein binding Hs molecular function 696 0.0
collagen binding Hs molecular function 693 0.0
ATP binding Hs molecular function 696 0.0
nucleus Hs cellular component 682 0.0
cytoplasm Hs cellular component 696 0.0
endosome Hs cellular component 696 0.0
cytosol Hs cellular component 696 0.0
plasma membrane Hs cellular component 696 0.0
cell-cell junction Hs cellular component 693 0.0
focal adhesion Hs cellular component 693 0.0
intercalated disc Hs cellular component 693 0.0
membrane Hs cellular component 693 0.0
kinase activity Hs molecular function 696 0.0
transferase activity Hs molecular function 696 0.0
Rho GTPase binding Hs molecular function 696 0.0
SH3 domain binding Hs molecular function 696 0.0
protein kinase binding Hs molecular function 693 0.0
Z disc Hs cellular component 693 0.0
lamellipodium Hs cellular component 693 0.0
cell junction Hs cellular component 693 0.0
protein tyrosine kinase activator activity Hs molecular function 682 0.0
axon Hs cellular component 693 0.0
dendrite Hs cellular component 693 0.0
small GTPase binding Hs molecular function 682 0.0
filamentous actin Hs cellular component 693 0.0
nuclear membrane Hs cellular component 693 0.0
ruffle membrane Hs cellular component 693 0.0
macromolecular complex Hs cellular component 693 0.0
identical protein binding Hs molecular function 682 0.0
cell projection Hs cellular component 693 0.0
cadherin binding Hs molecular function 682 0.0
metal ion binding Hs molecular function 696 0.0
Rac GTPase binding Hs molecular function 696 0.0
perinuclear region of cytoplasm Hs cellular component 682 0.0
GTPase binding Hs molecular function 696 0.0
invadopodium Hs cellular component 693 0.0

GO (InterProScan)

4 results

GO Term Analysis Type e-value
protein kinase activity SMART molecular function 3.0E-96
protein serine/threonine kinase activity CDD molecular function 1.40238E-23
ATP binding SMART molecular function 3.0E-96
protein phosphorylation SMART biological process 3.0E-96

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