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GENE CARD

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Gene Card

Best human hits

PROX1; PROX2

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00006599

Gene Model ID

KH2012:KH.C4.500

Location

KhC4:540367..547734

Transcript Models and Sequences

  KH2012:KH.C4.500.v1.B.SL1-1

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000013650
NCBI Reference Sequence XM_002122572.2
Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

4 results

IPR Term Analysis Definition
Homeobox-like_sf SUPERFAMILY Homeobox-like domain superfamily
Homeo_prospero_dom ProSiteProfiles Homeo-prospero domain
Homeo_prospero_dom Pfam Homeo-prospero domain
Homeo_prospero_dom_sf Gene3D Homeo-prospero domain superfamily

GOSlim

42 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II transcription factor activity, sequence-specific DNA binding Orthology molecular function
DNA binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
transcription corepressor activity Orthology molecular function
protein binding Orthology molecular function
nucleus Orthology cellular component
cytoplasm Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
multicellular organism development Orthology biological process
brain development Orthology biological process
positive regulation of cell proliferation Orthology biological process
negative regulation of cell proliferation Orthology biological process
regulation of gene expression Orthology biological process
neuron differentiation Orthology biological process
sequence-specific DNA binding Orthology molecular function
transcription regulatory region DNA binding Orthology molecular function
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
transcription regulatory region sequence-specific DNA binding Orthology molecular function
cell differentiation Orthology biological process
animal organ development Orthology biological process
vasculature development Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
anatomical structure morphogenesis Orthology biological process
receptor binding Orthology molecular function
transcription factor binding Orthology molecular function
central nervous system development Orthology biological process
nervous system development Orthology biological process
cell development Orthology biological process
regulation of molecular function Orthology biological process
cell cycle Orthology biological process
positive regulation of catalytic activity Orthology biological process
molecular transducer activity Orthology molecular function
protein serine/threonine kinase activity Orthology molecular function
blood vessel morphogenesis Orthology biological process
heart development Orthology biological process
cell morphogenesis involved in differentiation Orthology biological process
cell proliferation Orthology biological process
developmental process Orthology biological process

GO (Orthology)

66 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
core promoter sequence-specific DNA binding Hs molecular function
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function
cell fate determination Hs biological process
kidney development Hs biological process
liver development Hs biological process
positive regulation of endothelial cell proliferation Hs biological process
lymph vessel development Hs biological process
lymphangiogenesis Hs biological process
lens development in camera-type eye Hs biological process
lens morphogenesis in camera-type eye Hs biological process
DNA binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function
transcription corepressor activity Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
cytoplasm Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
multicellular organism development Hs biological process
brain development Hs biological process
circadian rhythm Hs biological process
positive regulation of cell proliferation Hs biological process
negative regulation of cell proliferation Hs biological process
regulation of gene expression Hs biological process
ligand-dependent nuclear receptor binding Hs molecular function
dorsal spinal cord development Hs biological process
cerebellar granule cell differentiation Hs biological process
neural tube development Hs biological process
neuron differentiation Hs biological process
skeletal muscle thin filament assembly Hs biological process
lung development Hs biological process
olfactory placode formation Hs biological process
pancreas development Hs biological process
response to nutrient levels Hs biological process
regulation of circadian rhythm Hs biological process
negative regulation of sequence-specific DNA binding transcription factor activity Hs biological process
sequence-specific DNA binding Hs molecular function
transcription regulatory region DNA binding Hs molecular function
negative regulation of viral genome replication Hs biological process
positive regulation of cyclin-dependent protein serine/threonine kinase activity Hs biological process
positive regulation of cell cycle Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
optic placode formation involved in camera-type eye formation Hs biological process
rhythmic process Hs biological process
inner ear development Hs biological process
venous blood vessel morphogenesis Hs biological process
DBD domain binding Hs molecular function
LBD domain binding Hs molecular function
ventricular cardiac myofibril assembly Hs biological process
cardiac muscle cell differentiation Hs biological process
ventricular cardiac muscle tissue morphogenesis Hs biological process
retina morphogenesis in camera-type eye Hs biological process
embryonic retina morphogenesis in camera-type eye Hs biological process
endocardium formation Hs biological process
positive regulation of sarcomere organization Hs biological process
lymphatic endothelial cell differentiation Hs biological process
lens fiber cell morphogenesis Hs biological process
hepatocyte differentiation Hs biological process
hepatocyte proliferation Hs biological process
neuronal stem cell population maintenance Hs biological process
positive regulation of neural precursor cell proliferation Hs biological process

GO (Blast)

15 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 261 1.07e-74
core promoter sequence-specific DNA binding Hs molecular function 261 1.07e-74
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function 261 1.07e-74
DNA binding Hs molecular function 261 1.07e-74
transcription factor activity, sequence-specific DNA binding Hs molecular function 261 1.07e-74
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function 261 1.07e-74
transcription corepressor activity Hs molecular function 261 1.07e-74
protein binding Hs molecular function 261 1.07e-74
nucleus Hs cellular component 261 1.07e-74
cytoplasm Hs cellular component 261 1.07e-74
ligand-dependent nuclear receptor binding Hs molecular function 261 1.07e-74
sequence-specific DNA binding Hs molecular function 261 1.07e-74
transcription regulatory region DNA binding Hs molecular function 261 1.07e-74
DBD domain binding Hs molecular function 261 1.07e-74
LBD domain binding Hs molecular function 261 1.07e-74

GO (InterProScan)

1 result

GO Term Analysis Type e-value
DNA binding Gene3D molecular function 5.8E-82

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