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  3. Gene 'KH2012:KH.C7.703' > 
  4. Gene 'KH2012:KH.C1.210' > 

Gene Card

Best human hits

TGFB1; TGFB2; TGFB3

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00005927

Gene Model ID

KH2012:KH.C3.724

Location

KhC3:6359981..6373769

Transcript Models and Sequences

  KH2012:KH.C3.724.v1.R.SL1-1
KH2012:KH.C3.724.v2.A.ND2-2
KH2012:KH.C3.724.v3.A.ND3-2

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000008565
NCBI Reference Sequence NM_001078370.1
Collections

Gateway full ORF

2 results

cima871542

Plate: VES66_A21

cima891799

Plate: VES70_O24

Gene collection 1 (N. Satoh)

1 result

ciad051d03

Plate: R1CiGC05m20

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

10 results

IPR Term Analysis Definition
TGF-beta PRINTS Transforming growth factor-beta
Cystine-knot_cytokine Gene3D Cystine-knot cytokine
TGF-b_C Pfam Transforming growth factor-beta, C-terminal
Cystine-knot_cytokine SUPERFAMILY Cystine-knot cytokine
TGFb_CS ProSitePatterns Transforming growth factor beta, conserved site
TGF-b_propeptide Pfam TGF-beta, propeptide
TGF-b_C SMART Transforming growth factor-beta, C-terminal
TGF-b_C ProSiteProfiles Transforming growth factor-beta, C-terminal
TGF-beta-rel PANTHER Transforming growth factor-beta-related
TGF-beta PIRSF Transforming growth factor-beta

GOSlim

122 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
cell morphogenesis Orthology biological process
angiogenesis Orthology biological process
response to hypoxia Orthology biological process
receptor binding Orthology molecular function
protein binding Orthology molecular function
extracellular region Orthology cellular component
extracellular space Orthology cellular component
nucleus Orthology cellular component
cytoplasm Orthology cellular component
plasma membrane Orthology cellular component
protein phosphorylation Orthology biological process
phosphate-containing compound metabolic process Orthology biological process
Notch signaling pathway Orthology biological process
cell-cell signaling Orthology biological process
heart development Orthology biological process
cell death Orthology biological process
cell proliferation Orthology biological process
positive regulation of cell proliferation Orthology biological process
negative regulation of cell proliferation Orthology biological process
response to wounding Orthology biological process
cell surface Orthology cellular component
response to organic substance Orthology biological process
regulation of gene expression Orthology biological process
positive regulation of gene expression Orthology biological process
negative regulation of gene expression Orthology biological process
cell migration Orthology biological process
cytokine-mediated signaling pathway Orthology biological process
enzyme binding Orthology molecular function
axon Orthology cellular component
wound healing Orthology biological process
regulation of cell proliferation Orthology biological process
identical protein binding Orthology molecular function
protein homodimerization activity Orthology molecular function
regulation of apoptotic process Orthology biological process
neuronal cell body Orthology cellular component
positive regulation of apoptotic process Orthology biological process
intracellular membrane-bounded organelle Orthology cellular component
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
protein heterodimerization activity Orthology molecular function
protein N-terminus binding Orthology molecular function
cell development Orthology biological process
neuron development Orthology biological process
generation of neurons Orthology biological process
intracellular signal transduction Orthology biological process
positive regulation of catalytic activity Orthology biological process
protein serine/threonine kinase activity Orthology molecular function
positive regulation of signal transduction Orthology biological process
system development Orthology biological process
binding Orthology molecular function
blood vessel morphogenesis Orthology biological process
cell differentiation Orthology biological process
animal organ development Orthology biological process
anatomical structure morphogenesis Orthology biological process
cellular process Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
nervous system development Orthology biological process
sodium ion transport Orthology biological process
immune system process Orthology biological process
membrane organization Orthology biological process
organelle organization Orthology biological process
molecular function regulator Orthology molecular function
regulation of signal transduction Orthology biological process
signaling receptor activity Orthology molecular function
Golgi apparatus part Orthology cellular component
intracellular organelle lumen Orthology cellular component
plasma membrane region Orthology cellular component
cell projection Orthology cellular component
cytoskeletal part Orthology cellular component
intracellular protein transport Orthology biological process
cell Orthology cellular component
defense response Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
cell division Orthology biological process
anatomical structure development Orthology biological process
developmental process Orthology biological process
DNA replication Orthology biological process
neurogenesis Orthology biological process
gamete generation Orthology biological process
reproductive process Orthology biological process
multicellular organism development Orthology biological process
regulation of molecular function Orthology biological process
extracellular matrix organization Orthology biological process
immune response Orthology biological process
central nervous system development Orthology biological process
cell adhesion Orthology biological process
cytoplasmic vesicle Orthology cellular component
endomembrane system Orthology cellular component
cellular component organization Orthology biological process
plasma membrane part Orthology cellular component
regulation of transcription from RNA polymerase II promoter Orthology biological process
negative regulation of signal transduction Orthology biological process
chemotaxis Orthology biological process
extracellular region part Orthology cellular component
cellular protein modification process Orthology biological process
intracellular organelle part Orthology cellular component
proteolysis Orthology biological process
mitotic cell cycle phase transition Orthology biological process
response to lipopolysaccharide Orthology biological process
protein kinase activity Orthology molecular function
response to lipid Orthology biological process
cellular response to stress Orthology biological process
protein dephosphorylation Orthology biological process
establishment of protein localization to organelle Orthology biological process
regulation of cellular metabolic process Orthology biological process
negative regulation of apoptotic process Orthology biological process
enzyme activator activity Orthology molecular function
protein kinase binding Orthology molecular function
response to stimulus Orthology biological process
cell cycle Orthology biological process
small GTPase mediated signal transduction Orthology biological process
protein transport Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
DNA binding Orthology molecular function
cell projection assembly Orthology biological process
head development Orthology biological process
apoptotic process Orthology biological process
protein localization to organelle Orthology biological process
protein localization to membrane Orthology biological process

GO (Orthology)

226 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
protein import into nucleus, translocation Hs biological process
negative regulation of transcription from RNA polymerase II promoter Hs biological process
MAPK cascade Hs biological process
activation of MAPK activity Hs biological process
cell morphogenesis Hs biological process
skeletal system development Hs biological process
angiogenesis Hs biological process
amyloid-beta binding Hs molecular function
vasculogenesis Hs biological process
eye development Hs biological process
ureteric bud development Hs biological process
response to hypoxia Hs biological process
morphogenesis of a branching structure Hs biological process
cell activation Hs biological process
kidney development Hs biological process
epithelial to mesenchymal transition Hs biological process
neural tube closure Hs biological process
negative regulation of protein phosphorylation Hs biological process
positive regulation of protein phosphorylation Hs biological process
regulation of sodium ion transport Hs biological process
chondrocyte differentiation Hs biological process
hematopoietic progenitor cell differentiation Hs biological process
tolerance induction to self antigen Hs biological process
platelet degranulation Hs biological process
heart morphogenesis Hs biological process
heart valve morphogenesis Hs biological process
atrioventricular valve morphogenesis Hs biological process
endocardial cushion morphogenesis Hs biological process
ventricular trabecula myocardium morphogenesis Hs biological process
neural retina development Hs biological process
antigen binding Hs molecular function
receptor binding Hs molecular function
type II transforming growth factor beta receptor binding Hs molecular function
cytokine activity Hs molecular function
transforming growth factor beta receptor binding Hs molecular function
protein binding Hs molecular function
extracellular region Hs cellular component
proteinaceous extracellular matrix Hs cellular component
extracellular space Hs cellular component
nucleus Hs cellular component
cytoplasm Hs cellular component
Golgi lumen Hs cellular component
plasma membrane Hs cellular component
microvillus Hs cellular component
protein phosphorylation Hs biological process
protein export from nucleus Hs biological process
ATP biosynthetic process Hs biological process
phosphate-containing compound metabolic process Hs biological process
cellular calcium ion homeostasis Hs biological process
inflammatory response Hs biological process
cell cycle arrest Hs biological process
mitotic cell cycle checkpoint Hs biological process
epidermal growth factor receptor signaling pathway Hs biological process
transforming growth factor beta receptor signaling pathway Hs biological process
Notch signaling pathway Hs biological process
cell-cell signaling Hs biological process
negative regulation of neuroblast proliferation Hs biological process
salivary gland morphogenesis Hs biological process
endoderm development Hs biological process
heart development Hs biological process
aging Hs biological process
growth factor activity Hs molecular function
negative regulation of DNA replication Hs biological process
cell death Hs biological process
cell proliferation Hs biological process
positive regulation of cell proliferation Hs biological process
negative regulation of cell proliferation Hs biological process
glial cell migration Hs biological process
germ cell migration Hs biological process
male gonad development Hs biological process
response to radiation Hs biological process
response to wounding Hs biological process
response to glucose Hs biological process
embryo development ending in birth or egg hatching Hs biological process
cell surface Hs cellular component
cardioblast differentiation Hs biological process
response to organic substance Hs biological process
regulation of gene expression Hs biological process
regulation of receptor activity Hs biological process
positive regulation of vascular endothelial growth factor production Hs biological process
positive regulation of gene expression Hs biological process
negative regulation of gene expression Hs biological process
negative regulation of extracellular matrix disassembly Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
positive regulation of peptidyl-threonine phosphorylation Hs biological process
positive regulation of pathway-restricted SMAD protein phosphorylation Hs biological process
negative regulation of macrophage cytokine production Hs biological process
oligodendrocyte development Hs biological process
positive regulation of phosphatidylinositol 3-kinase signaling Hs biological process
response to organic cyclic compound Hs biological process
cell growth Hs biological process
regulation of striated muscle tissue development Hs biological process
cell migration Hs biological process
negative regulation of angiogenesis Hs biological process
regulation of transforming growth factor beta receptor signaling pathway Hs biological process
cytokine-mediated signaling pathway Hs biological process
enzyme binding Hs molecular function
neural tube development Hs biological process
negative regulation of cell-cell adhesion Hs biological process
hemopoiesis Hs biological process
secretory granule Hs cellular component
collagen fibril organization Hs biological process
hyaluronan catabolic process Hs biological process
T cell differentiation Hs biological process
negative regulation of ossification Hs biological process
positive regulation of cell growth Hs biological process
negative regulation of cell growth Hs biological process
T-tubule Hs cellular component
embryonic limb morphogenesis Hs biological process
regulation of cell migration Hs biological process
positive regulation of cell migration Hs biological process
axon Hs cellular component
positive regulation of bone mineralization Hs biological process
BMP signaling pathway Hs biological process
negative regulation of transforming growth factor beta receptor signaling pathway Hs biological process
neutrophil chemotaxis Hs biological process
extracellular matrix Hs cellular component
positive regulation of histone deacetylation Hs biological process
platelet alpha granule lumen Hs cellular component
animal organ regeneration Hs biological process
membrane protein intracellular domain proteolysis Hs biological process
positive regulation of protein complex assembly Hs biological process
positive regulation of exit from mitosis Hs biological process
lipopolysaccharide-mediated signaling pathway Hs biological process
activation of protein kinase activity Hs biological process
response to estradiol Hs biological process
response to progesterone Hs biological process
receptor catabolic process Hs biological process
positive regulation of stress-activated MAPK cascade Hs biological process
positive regulation of peptidyl-serine phosphorylation Hs biological process
positive regulation of cell adhesion mediated by integrin Hs biological process
type I transforming growth factor beta receptor binding Hs molecular function
type III transforming growth factor beta receptor binding Hs molecular function
positive regulation of histone acetylation Hs biological process
positive regulation of protein dephosphorylation Hs biological process
wound healing Hs biological process
T cell activation Hs biological process
regulation of cell proliferation Hs biological process
regulation of protein import into nucleus Hs biological process
positive regulation of protein import into nucleus Hs biological process
dopamine biosynthetic process Hs biological process
odontogenesis Hs biological process
response to drug Hs biological process
myelination Hs biological process
identical protein binding Hs molecular function
protein homodimerization activity Hs molecular function
regulation of apoptotic process Hs biological process
myeloid dendritic cell differentiation Hs biological process
neuronal cell body Hs cellular component
T cell homeostasis Hs biological process
positive regulation of apoptotic process Hs biological process
intracellular membrane-bounded organelle Hs cellular component
positive regulation of MAP kinase activity Hs biological process
regulation of MAPK cascade Hs biological process
protein kinase B signaling Hs biological process
negative regulation of neuron apoptotic process Hs biological process
positive regulation of neuron apoptotic process Hs biological process
negative regulation of blood vessel endothelial cell migration Hs biological process
protein serine/threonine kinase activator activity Hs molecular function
response to estrogen Hs biological process
cell-cell junction organization Hs biological process
regulation of regulatory T cell differentiation Hs biological process
negative regulation of cell differentiation Hs biological process
positive regulation of DNA replication Hs biological process
positive regulation of Notch signaling pathway Hs biological process
negative regulation of cell cycle Hs biological process
positive regulation of cell cycle Hs biological process
positive regulation of heart contraction Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
negative regulation of mitotic cell cycle Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
negative regulation of Ras protein signal transduction Hs biological process
protein heterodimerization activity Hs molecular function
protein N-terminus binding Hs molecular function
somatic stem cell division Hs biological process
cell development Hs biological process
digestive tract development Hs biological process
embryonic digestive tract development Hs biological process
neuron development Hs biological process
generation of neurons Hs biological process
embryonic neurocranium morphogenesis Hs biological process
inner ear development Hs biological process
transforming growth factor beta binding Hs molecular function
positive regulation of epithelial cell proliferation Hs biological process
negative regulation of epithelial cell proliferation Hs biological process
positive regulation of protein secretion Hs biological process
positive regulation of peptidyl-tyrosine phosphorylation Hs biological process
negative regulation of immune response Hs biological process
positive regulation of immune response Hs biological process
negative regulation of T cell activation Hs biological process
leukocyte migration Hs biological process
positive regulation of chemotaxis Hs biological process
positive regulation of NF-kappaB transcription factor activity Hs biological process
regulation of DNA binding Hs biological process
positive regulation of filopodium assembly Hs biological process
positive regulation of stress fiber assembly Hs biological process
positive regulation of cell division Hs biological process
positive regulation of protein kinase B signaling Hs biological process
ventricular cardiac muscle tissue morphogenesis Hs biological process
palate development Hs biological process
cardiac muscle cell proliferation Hs biological process
uterus development Hs biological process
face morphogenesis Hs biological process
pathway-restricted SMAD protein phosphorylation Hs biological process
SMAD protein signal transduction Hs biological process
negative regulation of gene silencing by miRNA Hs biological process
regulation of cartilage development Hs biological process
pharyngeal arch artery morphogenesis Hs biological process
lens fiber cell differentiation Hs biological process
positive regulation of ERK1 and ERK2 cascade Hs biological process
positive regulation of cell cycle arrest Hs biological process
cellular response to mechanical stimulus Hs biological process
cellular response to organic cyclic compound Hs biological process
cellular response to ionizing radiation Hs biological process
cellular response to transforming growth factor beta stimulus Hs biological process
blood microparticle Hs cellular component
extracellular matrix assembly Hs biological process
positive regulation of branching involved in ureteric bud morphogenesis Hs biological process
extrinsic apoptotic signaling pathway Hs biological process
positive regulation of protein localization to nucleus Hs biological process
positive regulation of extracellular matrix assembly Hs biological process
negative regulation of protein localization to plasma membrane Hs biological process
cranial skeletal system development Hs biological process
regulation of actin cytoskeleton reorganization Hs biological process
positive regulation of cardiac muscle cell differentiation Hs biological process

GO (Blast)

34 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
amyloid-beta binding Hs molecular function 276 1.15e-88
antigen binding Hs molecular function 203 4.14e-61
receptor binding Hs molecular function 276 1.15e-88
type II transforming growth factor beta receptor binding Hs molecular function 276 1.15e-88
cytokine activity Hs molecular function 276 1.15e-88
transforming growth factor beta receptor binding Hs molecular function 276 1.15e-88
protein binding Hs molecular function 276 1.15e-88
extracellular region Hs cellular component 276 1.15e-88
proteinaceous extracellular matrix Hs cellular component 203 4.14e-61
extracellular space Hs cellular component 276 1.15e-88
nucleus Hs cellular component 252 1.22e-79
cytoplasm Hs cellular component 252 1.22e-79
Golgi lumen Hs cellular component 203 4.14e-61
plasma membrane Hs cellular component 252 1.22e-79
microvillus Hs cellular component 203 4.14e-61
growth factor activity Hs molecular function 276 1.15e-88
cell surface Hs cellular component 252 1.22e-79
enzyme binding Hs molecular function 203 4.14e-61
secretory granule Hs cellular component 252 1.22e-79
T-tubule Hs cellular component 252 1.22e-79
axon Hs cellular component 276 1.15e-88
extracellular matrix Hs cellular component 276 1.15e-88
platelet alpha granule lumen Hs cellular component 276 1.15e-88
type I transforming growth factor beta receptor binding Hs molecular function 252 1.22e-79
type III transforming growth factor beta receptor binding Hs molecular function 276 1.15e-88
identical protein binding Hs molecular function 252 1.22e-79
protein homodimerization activity Hs molecular function 276 1.15e-88
neuronal cell body Hs cellular component 276 1.15e-88
intracellular membrane-bounded organelle Hs cellular component 252 1.22e-79
protein serine/threonine kinase activator activity Hs molecular function 203 4.14e-61
protein heterodimerization activity Hs molecular function 276 1.15e-88
protein N-terminus binding Hs molecular function 203 4.14e-61
transforming growth factor beta binding Hs molecular function 252 1.22e-79
blood microparticle Hs cellular component 203 4.14e-61

GO (InterProScan)

2 results

GO Term Analysis Type e-value
extracellular space PIRSF cellular component 4.0E-95
growth factor activity SMART molecular function 1.7E-26

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