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Gene Card

Best human hits

SMAD1; SMAD5; SMAD9

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00004785

Gene Model ID

KH2012:KH.C2.573

Location

KhC2:3201112..3212869

Transcript Models and Sequences

  KH2012:KH.C2.573.v1.R.SL1-2
KH2012:KH.C2.573.v2.R.SL1-1
KH2012:KH.C2.573.v3.A.SL1-2

External Database Gene Card

External database links

3 results

Database Gene ID
ENSEMBL ENSCING00000005942
ENSEMBL ENSCING00000022875
NCBI Reference Sequence NM_001078347.1
Collections

Gateway full ORF

4 results

cien109309

Plate: VES87_A10

cima89470

Plate: VES57_F18

cima835044

Plate: VES62_M17

cien121231

Plate: VES89_G06

Gene collection 1 (N. Satoh)

1 result

cicl016e21

Plate: R1CiGC10g18

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term Analysis Definition
Dwarfin PANTHER Dwarfin
SMAD-like_dom_sf Gene3D SMAD-like domain superfamily
SMAD_dom_Dwarfin-type ProSiteProfiles SMAD domain, Dwarfin-type
SMAD_dom_Dwarfin-type SMART SMAD domain, Dwarfin-type
SMAD_dom_Dwarfin-type Pfam SMAD domain, Dwarfin-type
SMAD_FHA_dom_sf SUPERFAMILY SMAD/FHA domain superfamily
SMAD_MH1_sf SUPERFAMILY SMAD MH1 domain superfamily
MAD_homology1_Dwarfin-type SMART MAD homology 1, Dwarfin-type
MAD_homology1_Dwarfin-type Pfam MAD homology 1, Dwarfin-type
MAD_homology_MH1 ProSiteProfiles MAD homology, MH1
SMAD_MH1_sf Gene3D SMAD MH1 domain superfamily

GOSlim

55 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II regulatory region sequence-specific DNA binding Orthology molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Orthology molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Orthology molecular function
DNA binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
protein binding Orthology molecular function
intracellular Orthology cellular component
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
cytosol Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
transcription from RNA polymerase II promoter Orthology biological process
protein phosphorylation Orthology biological process
signal transduction Orthology biological process
gamete generation Orthology biological process
negative regulation of cell proliferation Orthology biological process
positive regulation of gene expression Orthology biological process
integral component of membrane Orthology cellular component
protein kinase binding Orthology molecular function
ubiquitin protein ligase binding Orthology molecular function
macromolecular complex Orthology cellular component
identical protein binding Orthology molecular function
protein homodimerization activity Orthology molecular function
sequence-specific DNA binding Orthology molecular function
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
metal ion binding Orthology molecular function
protein heterodimerization activity Orthology molecular function
intracellular signal transduction Orthology biological process
animal organ development Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
multicellular organism development Orthology biological process
cell differentiation Orthology biological process
organelle inner membrane Orthology cellular component
nuclear membrane Orthology cellular component
intracellular part Orthology cellular component
defense response Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
cell development Orthology biological process
peptidase activity, acting on L-amino acid peptides Orthology molecular function
enzyme binding Orthology molecular function
immune system process Orthology biological process
molecular transducer activity Orthology molecular function
brain development Orthology biological process
RNA processing Orthology biological process
negative regulation of gene expression Orthology biological process
heart development Orthology biological process
cell proliferation Orthology biological process
RNA binding Orthology molecular function
angiogenesis Orthology biological process

GO (Orthology)

66 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
MAPK cascade Hs biological process
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function
ossification Hs biological process
ureteric bud development Hs biological process
mesodermal cell fate commitment Hs biological process
DNA binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
signal transducer activity, downstream of receptor Hs molecular function
protein binding Hs molecular function
intracellular Hs cellular component
nucleus Hs cellular component
nuclear inner membrane Hs cellular component
nucleoplasm Hs cellular component
transcription factor complex Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
transcription from RNA polymerase II promoter Hs biological process
protein phosphorylation Hs biological process
inflammatory response Hs biological process
signal transduction Hs biological process
transforming growth factor beta receptor signaling pathway Hs biological process
gamete generation Hs biological process
germ cell development Hs biological process
negative regulation of cell proliferation Hs biological process
embryonic pattern specification Hs biological process
positive regulation of gene expression Hs biological process
integral component of membrane Hs cellular component
protein deubiquitination Hs biological process
DEAD/H-box RNA helicase binding Hs molecular function
protein kinase binding Hs molecular function
erythrocyte differentiation Hs biological process
BMP signaling pathway Hs biological process
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Hs molecular function
midbrain development Hs biological process
hindbrain development Hs biological process
primary miRNA processing Hs biological process
ubiquitin protein ligase binding Hs molecular function
macromolecular complex Hs cellular component
homeostatic process Hs biological process
identical protein binding Hs molecular function
protein homodimerization activity Hs molecular function
sequence-specific DNA binding Hs molecular function
positive regulation of osteoblast differentiation Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
metal ion binding Hs molecular function
protein heterodimerization activity Hs molecular function
cartilage development Hs biological process
cardiac muscle cell proliferation Hs biological process
cardiac muscle contraction Hs biological process
bone development Hs biological process
SMAD protein signal transduction Hs biological process
positive regulation of cartilage development Hs biological process
co-SMAD binding Hs molecular function
I-SMAD binding Hs molecular function
primary miRNA binding Hs molecular function
SMAD protein complex Hs cellular component
cellular response to organic cyclic compound Hs biological process
positive regulation of sprouting angiogenesis Hs biological process

GO (Blast)

30 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function 695 0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 699 0.0
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 699 0.0
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function 699 0.0
DNA binding Hs molecular function 699 0.0
transcription factor activity, sequence-specific DNA binding Hs molecular function 699 0.0
signal transducer activity, downstream of receptor Hs molecular function 699 0.0
protein binding Hs molecular function 699 0.0
intracellular Hs cellular component 699 0.0
nucleus Hs cellular component 699 0.0
nuclear inner membrane Hs cellular component 699 0.0
nucleoplasm Hs cellular component 699 0.0
transcription factor complex Hs cellular component 699 0.0
cytoplasm Hs cellular component 699 0.0
cytosol Hs cellular component 699 0.0
integral component of membrane Hs cellular component 699 0.0
DEAD/H-box RNA helicase binding Hs molecular function 699 0.0
protein kinase binding Hs molecular function 699 0.0
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Hs molecular function 699 0.0
ubiquitin protein ligase binding Hs molecular function 695 0.0
macromolecular complex Hs cellular component 699 0.0
identical protein binding Hs molecular function 699 0.0
protein homodimerization activity Hs molecular function 699 0.0
sequence-specific DNA binding Hs molecular function 699 0.0
metal ion binding Hs molecular function 699 0.0
protein heterodimerization activity Hs molecular function 699 0.0
co-SMAD binding Hs molecular function 699 0.0
I-SMAD binding Hs molecular function 699 0.0
primary miRNA binding Hs molecular function 699 0.0
SMAD protein complex Hs cellular component 699 0.0

GO (InterProScan)

6 results

GO Term Analysis Type e-value
transcription factor activity, sequence-specific DNA binding ProSiteProfiles molecular function 36.771
protein binding SUPERFAMILY molecular function 1.06E-91
intracellular PANTHER cellular component 6.9E-256
transcription factor complex ProSiteProfiles cellular component 36.771
regulation of transcription, DNA-templated PANTHER biological process 6.9E-256
transforming growth factor beta receptor signaling pathway Gene3D biological process 4.1E-65

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