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CIS-REGULATION

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  1. Region 'REG00001588' > 
  2. Transcript 'KH2012:KH.L4.23.v1.A...' > 
  3. Region 'REG00000076' > 
  4. Transcript 'KH2012:KH.C5.109.v9....' > 
  5. Region 'REG00001592'

Cis-regulatory Region

Name

Cirobu.REG.Kh2012.S544:4937-5236|Dmrt1

Short name

Dmrt1_-186bp (Tokuhiro et al., 2017)

Region ID

REG00001592

Status

Curated

Origin

natural region from C. robusta formely Ciona int. type A

Type of Activity

inactive_region

Author

Shin-ichi Tokuhiro ()

Annotator

Lea Girard (2023-03-10)

Curator

Marion Gueroult-Bellone (2023-03-21)

View position in WashU

Description

This -186bp fragment has no cis-regulatory activity.

Hierarchy of Regulatory Regions

Modification of Cirobu.REG.Kh2012.S544:4837-5236|Dmrt1 by deletion

Regulated gene(s)

KH2012:KH.S544.3 (DMRT1; DMRTA1; DMRTA2)

Construct(s) made to test this region

CONS00001681: p.Cirobu.REG.Kh2012.S544:4937-5236>LacZ

Show in situ data
Overview of functional TF binding sites in this region

4,9375,236

Motif Name Binding Factor(s) Sequence Position in Region Comment

Sequence

Aniseed Coordinates: [4,937 / 5,236] on scaffold KhS544

There are two TSS in this Dmrt1 upstream region. The sequence is 300bp long from the first TSS and 186bp long from the second TSS of Dmrt1. This element is not active in anterior neural a6.5 and vegetal cells.

Show sequence

Length: 300

CGCCTGTGCACCGCGCGATCGAAGACACACAGCGCTGACTAATTGACCAACACAAAAGCG
AGGAAAGAAAAAAAAGCGAAAACGAGAACGGGATATTAATTGTACACGATTGTGACGTAA
ATTCGAGGCATTTTTTCTTCCGAAATCGAGCGGTTTAAATACCTCGCGTCTTTATTAGGT
ACAATCATATTGCCTTGATACCTTGCTTAGAACAGTGAATACATATAAATCGTATTAAAA
GCTTTAGAGTGTTAAACCAAAGAGTTACAGAAATTATAGCAAACAGTTCGTTTAACTGGC

Reference(s)

Tokuhiro et al. (2017). Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd. PLoS Genet. 13(5):e1006741

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