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CIS-REGULATION

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  1. Region 'REG00001561'

Cis-regulatory Region

Name

Cisavi.REG.Ens81.R14:1337478-1337753_µPax3/7|Dmbx

Short name

C.savignyi Dmbx 276bp minimal enhancer / Pax3/7 mutated (Stolfi 2011)

Region ID

REG00001561

Status

Curated

Origin

engineered region from C.savignyi

Type of Activity

inactive_region

Author

Alberto Stolfi (2023-01-13)

Annotator

Marion Gueroult-Bellone (2023-01-13)

Curator

Marion Gueroult-Bellone (2023-01-13)

View position in WashU

Description

Disruption of the conserved Pax3/7 binding site abolishes enhancer activity. Ciona savignyi Dmbx has no gene model in ANISEED current version.

Hierarchy of Regulatory Regions

Regulated gene(s)
n/a
Construct(s) made to test this region

CONS00001637: p.Cisavi.REG.Ens81.R14:1337478-1337753_µPax3/7>GFP

Show in situ data
Overview of functional TF binding sites in this region

1,337,4781,337,753

Motif Name Binding Factor(s) Sequence Position in Region Comment

Sequence

Aniseed Coordinates: [1,337,478 / 1,337,753] on scaffold R14

The Pax3/7 putative binding site was mutated (uppercase letters).

Show sequence

Length: 276

cactttccgaatcaacgtccacacttggttaattgaaacttcaattccagctaaccatcg
gatattaatggaaatacgaaggtgaatcatctgccgttataagatcacaattacagattt
tacggacgacaaacgaaGGCCGaaattgccgcgctttgggaataattgaccctgctgcgc
gccaccttgcggttaacatttttcgtatttagggcgaggagtagtcgactatcgcacaac
aatcagcttcggtgcgacgtacgcagagacagacaa

Reference(s)

Stolfi et al. (2011). Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development 138(24):5429-39

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