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CIS-REGULATION

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  1. Region 'REG00001492'

Cis-regulatory Region

Name

Cirobu.REG.KH2012.L152:100246-101451|Islet

Short name

Islet -6240/-5035 (Stolfi 2010)

Region ID

REG00001492

Status

Curated

Origin

natural region from C. robusta formely Ciona int. type A

Type of Activity

regulatory_region
(complex_region)

Author

Alberto Stolfi (2019-02-26)

Annotator

Marion Gueroult-Bellone (2019-02-26)

Curator

Marion Gueroult-Bellone (2019-02-26)

View position in WashU

Description

This 1.2kb region upstream of Islet (KH:L152.2) drives strong reporter expression in atrial siphon muscle precursors and bipolar tail neuron. Compared to the larger fragments, it losts the ability to drive reporter activity in cholinergic neurons of the central nervous system and notochord.

Hierarchy of Regulatory Regions

Modification of Cirobu.REG.KH2012.L152:99298-102536|Islet by deletion

Regulated gene(s)

KH2012:KH.L152.2 (ISL1; ISL2; LHX9)

Construct(s) made to test this region

CONS00001654: p.Cirobu.REG.KH2012.L152:100246-101451>unc76::GFP

Show in situ data
Overview of functional TF binding sites in this region

100,246101,451

Motif Name Binding Factor(s) Sequence Position in Region Comment

Sequence

Aniseed Coordinates: [100,246 / 101,451] on scaffold KhL152

Cis-regulatory region located upstream of Islet (KH.L152.2) TSS (-6240/-5035bp). The sequence was given by the author.

Show sequence

Length: 1,206

tgttatcacaacactacaggccatgagatctatgatctataccgtctgttatatttagtg
gatttgtgattttaaccgaacaccttcactagtttaaaccaaccgacaactcaccgcgaa
caatcagcgaatatttcattaaaccgacaaaaatttccagttaatttaaaatatagtaag
ttggggtaagatgggacatgtttttattctcatctcgtcccatttggtagtcaacaaaga
atatttacagaattataaattgaaatatcttcacgaagagaaaaatattgttatttgtta
aaaacacgatcaggaaatatgggatattttgtgctaaccgtattcatatttgcaacccac
tgtgagttgcttcttataaggtttaacagccacggttttaactaaattttatttatttta
accttagcgtgttataacgactgttatttttctgttaattcccatttcttcgccatgtta
gttaatatgacttttgttattgtaattatataaaaatatattttttaaaataagtctaaa
agtaaatgtctaagttgtatttacaaatttccgcaccagaataggcagcaggcaaccgcg
gatcgaaacaagtccctgatttatggttttgttgcaactaattatggctgtacagcacac
aggtcccaggattgccgtaaaacttaatttgctggaatatgttgaacaacagttgttaca
ttctgttgttttattaagttcagcggccacgcttttttaagccttttattccagtatttt
cgctcgtagcgtgttgataacgactgttgttttgctgctaattctcttcgttgttttaat
taaacttcgctatcgtattcaaaatatgttcatttagttggtaggttatgtgtgtaagtg
acatcataacaacttgtatgaggcaaacaaggggttatgacgtaataatagaattattga
tgtttcacagggtgaggtgtgacgtaataatagttctgacagttaaagtgattttgaata
aaaacaaaaaacagaatgtttaagtcgcgaaaatcgcgtgggcagcgttaaccagagcat
cgcatgtgacaagcgaacgaaatcccagcagatctacgacgttggtccgctgagagttcg
agcgaattcgggatgtaacgtcgatgaaagacgaaaagcggtccttgcctcgacaagaaa
ggacga

Reference(s)

Stolfi et al. (2010). Early chordate origins of the vertebrate second heart field. Science 329(5991):565-8

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