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CIS-REGULATION

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  1. Transcript 'KH2012:KH.L152.2.v1....' > 
  2. Molecular Tool 'Hr-FGF9/16/20 MO (Kumano 2006)' > 
  3. Transcript 'KH2012:KH.L9.13.v2.B...' > 
  4. Region 'REG00000874' > 
  5. Region 'REG00001491'

Cis-regulatory Region

Name

Cirobu.REG.KH2012.L152:101452-102530|Islet

Short name

Islet -5035/-3950 (Stolfi 2010)

Region ID

REG00001491

Status

Curated

Origin

natural region from C. robusta formely Ciona int. type A

Type of Activity

regulatory_region
(complex_region)

Author

Alberto Stolfi (2019-02-26)

Annotator

Marion Gueroult-Bellone (2019-02-26)

Curator

Marion Gueroult-Bellone (2019-02-26)

View position in WashU

Description

This region upstream of Islet (KH:L152.2) drives reporter expression in atrial siphon muscle precursors and cholinergic neurons of the central nervous system. Compared to the larger fragment, it losts the ability to drive reporter expression in notochord and bipolar tail neurons.

Hierarchy of Regulatory Regions

Modification of Cirobu.REG.KH2012.L152:99298-102536|Islet by deletion

Regulated gene(s)

KH2012:KH.L152.2 (ISL1; ISL2; LHX9)

Construct(s) made to test this region

CONS00001653: p.Cirobu.REG.KH2012.L152:101452-102530>unc76::GFP

Show in situ data
Overview of functional TF binding sites in this region

101,452102,530

Motif Name Binding Factor(s) Sequence Position in Region Comment

Sequence

Aniseed Coordinates: [101,452 / 102,530] on scaffold KhL152

Cis-regulatory region located upstream of Islet (KH.L152.2) TSS (-5035/-3950bp).

Show sequence

Length: 1,079

accgcgcgatagtagattttatggcgtatggtgttctataacacagctgtgggttgaagt
ggtttcgaatatttaagcaaggtacgacttgaccggttacgtcactttgaccacgtggtc
agctctcatcaatatttattttaaatttgattaaacagcgacctcaggtgagcggcctaa
ttatgcgcctctatgacgtcatagtttaaacttcttttaatagcggaatcgaagataaat
aggttgcgttaccctgggggtcgagatccaaatttcgttacttcgattgtttaattgatt
cgacatcgagttaaagcgcgagatttgattacatttccattgttcaatccataattcgct
ttgtgacgtaacacaaacttaacaaacacgtggtagcgcgcaagagctaattttttaaac
gtttcttgattttttttcgattttttttattaaaaaataaaataaattaatattttgttg
aaatacgtcgaaaccgcgaaaacgcgatcgacgcaattcaatttgtaaatgaaatatcga
ccagtggcgccgatagcggataatcctcacaattcttgtgataaattagtttcttactcg
gataatctgtgtgccggtttgattgtcgcacccaaggtgattggggggggggggatatta
cgtcattatgacaaataatttcgattaaaattggtaaaaatataaattaggggagttttt
agttttgttttaaaagattttatttaaaaattaaaaaaaaaatcgaaaatttttgaattt
gatcgattagctgtaattacgtcatcaatccgctcattatgacgtcatacgtcgccatat
tgcgtcataatcgggcgtcagaatgtcgtcacaaaccatattgtgttgaattaattggaa
ttatgaaacgccgctcggtcgggggatttgtgacgtcacaaacgtgaatgttacgacaca
aacggcgaactcgggcgaacttttagctttgcggataataagggtaagtgacgcaacaat
gacgcaacaatgttgtcccttgtgacgtaacagagtgtattgtaaccgttgaattgagt

Reference(s)

Stolfi et al. (2010). Early chordate origins of the vertebrate second heart field. Science 329(5991):565-8

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