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CIS-REGULATION

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  1. Region 'REG00001305'

Cis-regulatory Region

Name

Cirobu.REG.KH2012.S654:27045-27067|Tbx6.b

Short name

Tbx6.b_-130/-108pb

Region ID

REG00001305

Status

Curated

Origin

natural region from C. robusta formely Ciona int. type A

Type of Activity

regulatory_region
(enhancer)

Author

Izumi Oda-Ishii (2018-03-27)

Annotator

Marion Gueroult-Bellone (2018-03-27)

Curator

Marion Gueroult-Bellone (2018-03-27)

View position in WashU

Description

This short sequence, located between the two Tcf7 binding site behave as a silencer for anterior vegetal domain.

Hierarchy of Regulatory Regions

Modification of Cirobu.REG.KH2012.S654:26922-27123|Tbx6.b by deletion

Regulated gene(s)

KH2012:KH.S654.3 (TBX2; TBX4; TBX6)

Construct(s) made to test this region

CONS00001107: p.Cirobu.REG.KH2012.C2.4475337-4475581_(Cirobu.REG.KH2012.S654:27045-27068)x4>GFP

CONS00001108: P.Cirobu.REG.KH2012.C8:2621713-2622953_(Cirobu.REG.KH2012.S654:27045-27068)x4>GFP

Show in situ data
Overview of functional TF binding sites in this region

27,04527,067

Motif Name Binding Factor(s) Sequence Position in Region Comment

Sequence

Aniseed Coordinates: [27,045 / 27,067] on scaffold KhS654

This sequence inhibits enhancer activity in anterior vegetal domain.

Show sequence

Length: 23

ctctcctgctgattcgtgtctag

Reference(s)

Oda-Ishii et al. (2016). A Maternal System Initiating the Zygotic Developmental Program through Combinatorial Repression in the Ascidian Embryo. PLoS Genet. 12(5):e1006045

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