Description

Hierarchy of Regulatory Regions

Regulated gene(s)

KH2012:KH.C10.174 (MEIS1; MEIS2; MEIS3)

Construct(s) made to test this region

CONS00001168: pCES.Cirobu.REG.KH2012.C10:3153026-3153248:prCirobu.bpFoxAa>LacZ

Overview of functional TF binding sites in this region

3,153,0263,153,248

	Motif Name	Binding Factor(s)	Sequence	Position in Region	Comment

Sequence

Aniseed Coordinates: [3,153,026 / 3,153,248] on scaffold KhC10

This sequence is a non-coding element conserved between Ciona intestinalis and Ciona savignyi. Original comment : These Ciona conserved non-coding elements (ciCNEs) are associated with largely the same key regulatory genes as vertebrate CNEs. When tested in zebrafish embryos, this cis-regulatory region is weakly active in a mixed population of sensory and interneurons.

Reference(s)

Doglio et al. (2013). Parallel evolution of chordate cis-regulatory code for development. PLoS Genet. 9(11):e1003904