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CIS-REGULATION

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  1. Region 'REG00000896'

Cis-regulatory Region

Name

Ci-Pitx -323/-163

Short name

n/a

Region ID

REG00000896

Status

Curated

Origin

natural region from C. robusta formely Ciona int. type A

Type of Activity

regulatory_region
(enhancer)

Author

Yoshida Keita (2011-08-10)

Annotator

Marion Gueroult-Bellone (2011-08-10)

Curator

Delphine Dauga (2011-08-10)

View position in WashU

Description

The region from -3853 bp upstream the +1 to 147 pb downstream is an extended promoter which drives Ci-Pitxc expression.
This region contains one essential cis-regulatory elements.

Region -323 bp/-163 bp : it contains one Fox binding site. Removal of this site drives no expression in the epidermis.

Hierarchy of Regulatory Regions

Modification of Ci-Pitx -553/147 by deletion

Regulated gene(s)

KH2012:KH.L153.79 (PITX1; PITX2; PITX3)

Construct(s) made to test this region

CONS00000862: pCi-Pitx -323/-163::LacZ

Show in situ data
Overview of functional TF binding sites in this region

00

Motif Name Binding Factor(s) Sequence Position in Region Comment

Sequence

Aniseed Coordinates: [0 / 0] on scaffold

The sequence was based on JGI V1.0. The nucleotide +1 taken in reference corresponds to the first codon.

Show sequence

Length: 160

TGGAATTTTAGATTGTTAATCCTATTTCGCGTCTACTATTTCATTATATACCATACGCGT
TGTCACCTGTGTGACGTCATAATACGGAATTGTTCATTTATCATAGAAAAAACTGTCACG
AATTTTTATTATCATTTAAAAACAAATATTATTTGACAGC

Reference(s)

Yoshida et al. (2008). Left-right asymmetric expression of Pitx is regulated by the asymmetric Nodal signaling through an intronic enhancer in Ciona intestinalis. Dev. Genes Evol. 218(7):353-60

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