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CIS-REGULATION

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  1. Region 'REG00000628'

Cis-regulatory Region

Name

Ci-troponin I -765/66 Tbx6/MyoD mutated

Short name

n/a

Region ID

REG00000628

Status

Curated

Origin

engineered region from C. robusta formely Ciona int. type A

Type of Activity

regulatory_region
(extended_promoter)

Author

Christopher D. Brown (2009-12-13)

Annotator

Clara Degos (2010-07-23)

Curator

Delphine Dauga (2010-02-26)

View position in WashU

Description

Transcription start site is based on the start of the first exon of the KH transcript model.

Construct #1492 in the paper. In this construction the Tbx6 and MyoD sites were mutated.

Hierarchy of Regulatory Regions

Modification of Ci-troponin I -765/66 Tbx6 mutated by substitution

Regulated gene(s)

KH2012:KH.C11.673 (TNNI1; TNNI2; TNNI3)

Construct(s) made to test this region

CONS00000598: pCi-troponin I -765/66 Tbx6/MyoD mutated::LacZ

Show in situ data
Overview of functional TF binding sites in this region

1,684,4501,685,254

Motif Name Binding Factor(s) Sequence Position in Region Comment
1 bZIP n/a TGACGTCA [-755 / -748]

Sequence

Aniseed Coordinates: [1,684,450 / 1,685,254] on scaffold KhC11

Transcription start site is based on the start of the first exon of the KH transcript model. In this construction the Tbx6 and MyoD sites mutated were remplaced by "-"

Show sequence

Length: 831


T--------GTGACGTCATACTG------TTATCGCCTGAGCAGCAGTGTTCCCCGTGAT
TTTTTGCTGTGATTCAAATTTATTGATTACAAATATAAAAATTATATTATATTATACTTA
ATCAATGTAAAGTATTGATATAAGCATATTTCGTTAATTTAACCGAAATTAGCTATAGTT
TAAGCAGTTTCCAGAGGTTTACATTAGTACGGCGGCAACACTCGTTCTATATTAAATCCA
GACAACAAGAACTTCTTCTTCGTTTAGTCCTTCGATATTCTATTTAAGGGAGCTTACAGC
ATCCATCCAACATCGGTAATCAAGAATCTGTTAACCTTGTTTAGTCACAGAGAAAGGTTC
ATGCATTTAAGAACCCCTTAGTGAATTTAAAGAATTTTCTTGTAGAAAGGGCCGCATAGT
GGCCATGAATACTATGGTTAACTATTAGCTTAGTTGAGTTTATCATGCTCAATATTTTTA
TCATTTAGATTTTCTGAAGGGTTTAAAATTAAAAGCCTATTAAGCATATTTATTTAAATA
TAAGTTTATCCTCTCAGGGTTGTGATAGTGATAACTTATCAGGATTTATAACTATAGCGC
AATACTGAATTTATCAAGCTGATAAGACTACCAGTACCTGCGTAAAACCTTTAGGAAGTC
TAAATAGATACTTACTCTTCAGTAACTGAATGCAACCTGTATAAACGGAATATTGCAGAG
TTATATTTTTATCGTTTATATCCTTGTAGTTCACTAATGCATTTTCATCTTCAGCAGTAT
CAATTGGTTAAGTAGGTCTTAGTTTGGCTTAGCAACACAGCAAAACAGCAC

Reference(s)

Brown et al. (2007). Functional architecture and evolution of transcriptional elements that drive gene coexpression. Science 317(5844):1557-60

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