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CIS-REGULATION

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  1. Region 'REG00000614'

Cis-regulatory Region

Name

Ci-troponinT -2191/74 mutated

Short name

n/a

Region ID

REG00000614

Status

Curated

Origin

engineered region from C. robusta formely Ciona int. type A

Type of Activity

regulatory_region
(extended_promoter)

Author

Christopher D. Brown (2009-12-12)

Annotator

Clara Degos (2010-07-23)

Curator

Delphine Dauga (2010-02-26)

View position in WashU

Description

Transcription start site is based on the start of the first exon of the KH transcript model.

Construct #1610 in the paper. In this construct, the region deleted contains the Tbx6 and the three CRE regulatory motifs.

Hierarchy of Regulatory Regions

Modification of Ci-troponinT -2191/74 by substitution

Regulated gene(s)

KH2012:KH.C4.57 (TNNT1; TNNT2; TNNT3)

Construct(s) made to test this region

CONS00000584: p Ci-troponinT -2191/74 mutated::LacZ

Show in situ data
Overview of functional TF binding sites in this region

5,221,7855,224,053

Motif Name Binding Factor(s) Sequence Position in Region Comment

Sequence

Aniseed Coordinates: [5,221,785 / 5,224,053] on scaffold KhC4

Transcription start site is based on the start of the first exon of the KH transcript model. The region mutated (with the Tbx6 and the three CRE sites) was remplaced by "-".

Show sequence

Length: 2,267

TTAAAGATTTGGAAAACCGTGGCAATCCTCGTACTTAGACCTTCATTTCTTCTGAACTTT
TTCTTATAATGCGGTTGTTATGTTAAAACGAGCGAAAATTTCGGTGTTTTCCAACCAGCA
ATCTCGTGTGCAAAATTTCGAAGCAAATTTAATTCCTAAGTTTCAAAAACCTATTAATCG
TGAAGCTAGTCTCAATTATCTTTGATACAGCCACCCGCACCCACACGCGTGCTAATGTAG
CAGCCTCTGTTGCCTTTTGACTGCAAAAAGTTCTGCGTGTTGTACCTGCGTTGTTATATA
ATATATGCTCGTTTGTTGAATCAAATCGATGAAGCATAAATGACCAAATGTAGCTCTCTG
TTTGTTTTGAATGGTGAAAATAAATTACTTCCGCGTATCTGTTCTTATTTGTTCCTACTT
GTCAGTGGATACATCTATTCAACCAAAGGTTAGCGGGTTCAAGGCTCGATGCCGCTACCA
TTGTGGTCAATGTGTCCTTGCTCTCCAACCAAGTGGTCACTAATGACAAAAAACTAAGTC
ATCCATAAACTCGTAAGAACAGGGTTTATGAAACATAACACCCATGTTATAGCAGATAAA
ATGAATTACCATAAATCATCATTACAATATAGCTTTTAGTCCCGATTTGATCAAACACAA
TTTCCACAAATTACTAGTTTCACACTATGCAACTGTGACGAAGTATTACCACATTCTTAA
GGTGTAGTAAAGTATAACTTCAAATTTATTTTAGTTTGGAATCTTAAATGGCTTGAATCT
TGCCGCAATTTTAAACTATAGATCTATAACTAGTCAGTGAAAATTATAAAGCATGTATTC
CCATAGGGCTGACGAGTCTTGAACCAGATTCCTACACGACTATATAATGTTTTATTTCAA
GCGTTTTCAAATGTTTTAATGTCTTAGGGCACTTCTAGGCAATGCGACTCCAGACATGCA
TGGCAGTAAGGTAATGTTATAAGCAAAAGGATAGCACAATGATGGATACAAAATATGATT
TAAATGGATTACGTTTTAACTATATAGCAATGCAAAAATGGCAACTAGTTTTACAAATTT
AATAAAACAGTAATGCAGTCTCCTTGTGTCGTGTGTCAAATGTGACATTGTTTATTAATT
TTGGGCTTAATTGATTTCAAGACGTCCCGGTCGTTACGTTGGTCGTTTCATTCACATATG
CAGTTTATTATTACGCCGGCATGCGCACCGCTATGTGAGTCAGCCGTAAATATGAAACAC
AGCCATTGCTACATACATTTGACTGACACTCGCATCACTTCGCACATACTGAAGACTCAA
TCATGCTTTATGTCTCATCACACGCACACACCGCGTGCCAGGCCAACTAATCGCTAATTG
AAGCTCCAACAGCCGCTCGTCGCCTCAAACCCTACGTCACTCTTCGATATAACCGCCCAA
TAGGAGCGCTGTATTTTGGCACGTGACATTATACACTATTTTCGTGCATACAACGCTCAG
GGTGCCTGGATAGTCAGGCAAGACACCCTGATAGCAACCAGATGCTGGTATTACAATACG
AGGCAATAAAGCGGCCTAGATAGATAGTAAGAGGCGAGAAACGGTCGAATGCATTGCGAG
TATCAAGCAGCGATCCCAGCTCCGCTTCGATTGT--------------------------
----------------------------------------TTTGAAAAAAAGGTTGAGTC
TTATTCTATAAAAGGTTGGTCGGCAGCAACATAATCATTATCGAAGTCGCTTCAGCTTCA
TTCCATTCCTACTTCAAAGCATCAGCTTCTCAGGTCTTAAAGTTGTAGCTTCAATATGTT
CATACAGAACCAAGCAACAATTATTCAATATAGAAAAAGCAGTTCAGAAAGTTTATCTTT
GGCATAAATGTGACGTCATAGTGACGTACTCGGTAATCTATTTCACCGGTGCAATTTGCC
AATTAGATTAATTTGGTTAAACCAAGGTATTCGAGAAATATGTTTCGCACAGTCGAATAT
CTGCTTGTGATGTCATAAGCCAGCAACGTAGACAGACGTATCTTCAGCTGTCGTTCTGTG
ACGTCATAGTGGTATCGGCGCATTGTGCCGCGGTCGGCACCCATGGTCCAGTGACCATAT
AAGTTCATGTTGTTTTCTTTCCATCACCAGGTTATAACTTGATTAGACTTTCTTACCTGA
CTTGACCGTTTGCTCAAAAATGTCGGACTCAGAAGAATACAGCAGCG

Reference(s)

Brown et al. (2007). Functional architecture and evolution of transcriptional elements that drive gene coexpression. Science 317(5844):1557-60

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