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CIS-REGULATION

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  1. Region 'REG00000506'

Cis-regulatory Region

Name

Ci-tropomyosin 3 -102/82 Tbx6-2>MyoD

Short name

n/a

Region ID

REG00000506

Status

Curated

Origin

engineered region from C. robusta formely Ciona int. type A

Type of Activity

regulatory_region
(extended_promoter)

Author

Christopher D. Brown (2009-12-10)

Annotator

Clara Degos (2009-12-10)

Curator

Delphine Dauga (2010-02-26)

View position in WashU

Description

Transcription start site is based on the start of the first exon of the KH transcript model. This region corresponds to construct 1695 in the paper. Tbx6-2 motif was replaced by MyoD motif.

Hierarchy of Regulatory Regions

Modification of Ci-tropomyosin 3 -102/82 by substitution

Regulated gene(s)

KH2012:KH.C3.661 (TPM1; TPM3; TPM4)

Construct(s) made to test this region

CONS00000477: pCi-tropomyosin 3 -102/82 Tbx6>MyoD::LacZ

Show in situ data
Overview of functional TF binding sites in this region

4,367,4914,367,665

Motif Name Binding Factor(s) Sequence Position in Region Comment
1 bHLH n/a CAGCTG [-100 / -95]
2 bZIP n/a TGACCTAA [-82 / -75]
3 bZIP n/a TGACGTCA [-70 / -63]
4 T-Box n/a TTATCACTT [-58 / -50]

Sequence

Aniseed Coordinates: [4,367,491 / 4,367,665] on scaffold KhC3

Transcription start site is based on the start of the first exon of the KH transcript model. Tbx6-2 motif (TTCCTCACC) was replaced by MyoD motif (CAGCTG).

Show sequence

Length: 183


--CAGCTGTCTATATAGAATGACCTAATTGATGACGTCAAGCATTATCACTTCTACATTG
GCTATATAAGAGCGAAGTTGCCTTGTTATGCATCACACACAGTCGATTCTCACTCCACAG
CAGCACATTACTTCAACTAACTTGCAAAATGGAATCAATCAAGCACAAGATGGAAGGTCT
TAT

Reference(s)

Brown et al. (2007). Functional architecture and evolution of transcriptional elements that drive gene coexpression. Science 317(5844):1557-60

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