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CIS-REGULATION

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  1. Region 'REG00000504'

Cis-regulatory Region

Name

Ci-tropomyosin 3 -102/82 CRE-2 mutated

Short name

n/a

Region ID

REG00000504

Status

Curated

Origin

engineered region from C. robusta formely Ciona int. type A

Type of Activity

regulatory_region
(extended_promoter)

Author

Christopher D. Brown (2009-12-09)

Annotator

Clara Degos (2009-12-09)

Curator

Delphine Dauga (2010-02-26)

View position in WashU

Description

Transcription start site is based on the start of the first exon of the KH transcript model. This region corresponds to construct 1438 in the paper. The construction is mutated in the second CRE regulatory region.

Hierarchy of Regulatory Regions

Modification of Ci-tropomyosin 3 -102/82 by substitution

Regulated gene(s)

KH2012:KH.C3.661 (TPM1; TPM3; TPM4)

Construct(s) made to test this region

CONS00000475: pCi-tropomyosin 3 -102/82 CRE-2::LacZ

Show in situ data
Overview of functional TF binding sites in this region

4,367,4824,367,665

Motif Name Binding Factor(s) Sequence Position in Region Comment
1 T-Box n/a TTCCTCACC [-102 / -94]
2 bZIP n/a TGACCTAA [-82 / -75]
3 T-Box n/a TTATCACTT [-58 / -50]

Sequence

Aniseed Coordinates: [4,367,482 / 4,367,665] on scaffold KhC3

Transcription start site is based on the start of the first exon of the KH transcript model. CRE-2 Binding site mutated (TGACGTCA) was replaced by "-".

Show sequence

Length: 184


TTCCTCACCTCTATATAGAATGACCTAATTGA--------AGCATTATCACTTCTACATT
GGCTATATAAGAGCGAAGTTGCCTTGTTATGCATCACACACAGTCGATTCTCACTCCACA
GCAGCACATTACTTCAACTAACTTGCAAAATGGAATCAATCAAGCACAAGATGGAAGGTC
TTAT

Reference(s)

Brown et al. (2007). Functional architecture and evolution of transcriptional elements that drive gene coexpression. Science 317(5844):1557-60

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