Description

Transcription start site is based on the start of the first exon of the KH transcript model.


Coordinates and corresponding name in the paper : -1135/-840.

Hierarchy of Regulatory Regions

Modification of FoxF -2989/64 by deletion

Regulated gene(s)

KH2012:KH.C3.170 (FOXF1; FOXF2; FOXL1)

Construct(s) made to test this region

CONS00001657: p.FoxF -1072/-777>nls::LacZ

CONS00001549: p.FoxF -1072/-777>LacZ

CONS00001548: FoxF -1072/-777>Venus

CONS00001275: p.FoxF -1072/-777>mCherry

CONS00001502: Ci-FoxF -1072/-777>RFP

CONS00000193: pFoxF -1072/-777 pfkh::LacZ

CONS00001274: p.FoxF -1072/-777>GFP

Overview of functional TF binding sites in this region

3,598,2493,598,543

	Motif Name	Binding Factor(s)	Sequence	Position in Region	Comment
1	Ets	n/a	AGGATT	[-930 / -925]
2	bHLH	n/a	CACTTG	[-914 / -909]
3	Ets	n/a	AGGATG	[-888 / -883]
4	Ets	n/a	TTTCCG	[-797 / -792]

Sequence

Aniseed Coordinates: [3,598,249 / 3,598,543] on scaffold KhC3

This sequence was found in the paper.

Reference(s)

Beh et al. (2007). FoxF is essential for FGF-induced migration of heart progenitor cells in the ascidian Ciona intestinalis. Development 134(18):3297-305

Stolfi et al. (2014). Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians. Elife 3():e03728

Stolfi et al. (2010). Early chordate origins of the vertebrate second heart field. Science 329(5991):565-8

Razy-Krajka et al. (2018). An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time. Elife 7():

Davidson et al. (2006). FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis. Genes Dev. 20(19):2728-38